biostudies-literatureZheng ZNational Natural Science Foundation of ChinaNational Institutes of HealthNational Institute of General Medical SciencesNIH HHSNIGMS NIH HHS17398-17402https://www.ebi.ac.uk/biostudies/studies/S-EPMC7759593biostudies-literatureUnknown59(40)Cyclobutanones are synthetically versatile compounds that often require extensive effort to access. Herein, we report a facile synthesis of cyclobutanones based on the C(sp³ )-H insertion chemistry of oxidatively generated gold carbenes. Various cyclobutanones were obtained in synthetically useful yields from substrates with minimal structural prefunctionalization. This discovery reveals new synthetic utilities of gold-catalyzed oxidative transformations of alkynones.Angewandte Chemie (International ed. in English)Non-Diazo C-H Insertion Approach to Cyclobutanones through Oxidative Gold Catalysis.PMC7759593R01GM12334221672247S10OD012077S10 OD012077R01 GM123342Zheng ZLi YMa XZhang LWang YfalseNon-Diazo C-H Insertion Approach to Cyclobutanones through Oxidative Gold Catalysis.Cyclobutanones are synthetically versatile compounds that often require extensive effort to access. Herein, we report a facile synthesis of cyclobutanones based on the C(sp³ )-H insertion chemistry of oxidatively generated gold carbenes. Various cyclobutanones were obtained in synthetically useful yields from substrates with minimal structural prefunctionalization. This discovery reveals new synthetic utilities of gold-catalyzed oxidative transformations of alkynones.2020-01-01T00:00:00Z2020 Sep2024-02-15T17:24:06.72Z2022-02-11T11:20:51.873ZS-EPMC77595933258507610.1002/anie.202003698