{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alnafakh R"],"funding":["North West Cancer Research Fund","Wellbeing of Women","Higher Committee for Education Development in Iraq"],"pagination":["E588"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7764055"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(12)"],"pubmed_abstract":["Telomeres protect chromosomal ends and they are maintained by the specialised enzyme, telomerase. Endometriosis is a common gynaecological disease and high telomerase activity and higher hTERT levels associated with longer endometrial telomere lengths are characteristics of eutopic secretory endometrial aberrations of women with endometriosis. Our ex-vivo study examined the levels of hTERC and DKC1 RNA and dyskerin protein levels in the endometrium from healthy women and those with endometriosis (<i>n</i> = 117). The in silico study examined endometriosis-specific telomere- and telomerase-associated gene (TTAG) transcriptional aberrations of secretory phase eutopic endometrium utilising publicly available microarray datasets. Eutopic secretory endometrial hTERC levels were significantly in"],"journal":["Biomedicines"],"pubmed_title":["Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study."],"pmcid":["PMC7764055"],"funding_grant_id":["Mres projects","RG2137","RA thesis","RG1487","RG1073"],"pubmed_authors":["Bradfield A","Alnafakh R","Hapangama DK","Choi F","Saretzki G","Adishesh M"],"additional_accession":[]},"is_claimable":false,"name":"Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study.","description":"Telomeres protect chromosomal ends and they are maintained by the specialised enzyme, telomerase. Endometriosis is a common gynaecological disease and high telomerase activity and higher hTERT levels associated with longer endometrial telomere lengths are characteristics of eutopic secretory endometrial aberrations of women with endometriosis. Our ex-vivo study examined the levels of hTERC and DKC1 RNA and dyskerin protein levels in the endometrium from healthy women and those with endometriosis (<i>n</i> = 117). The in silico study examined endometriosis-specific telomere- and telomerase-associated gene (TTAG) transcriptional aberrations of secretory phase eutopic endometrium utilising publicly available microarray datasets. Eutopic secretory endometrial hTERC levels were significantly in","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-05-02T06:38:27.32Z","creation":"2021-02-20T17:38:57Z"},"accession":"S-EPMC7764055","cross_references":{"pubmed":["33317189"],"doi":["10.3390/biomedicines8120588"]}}