biostudies-literatureBroome DTNIDDK NIH HHSNational Institutes of Health237-250https://www.ebi.ac.uk/biostudies/studies/S-EPMC7765647biostudies-literatureUnknown106(1)Maturity-onset diabetes of the young, or MODY-monogenic diabetes, is a not-so-rare collection of inherited disorders of non-autoimmune diabetes mellitus that remains insufficiently diagnosed despite increasing awareness. These cases are important to efficiently and accurately diagnose, given the clinical implications of syndromic features, cost-effective treatment regimen, and the potential impact on multiple family members. Proper recognition of the clinical manifestations, family history, and cost-effective lab and genetic testing provide the diagnosis. All patients must undergo a thorough history, physical examination, multigenerational family history, lab evaluation (glycated hemoglobin A1c [HbA1c], glutamic acid decarboxylase antibodies [GADA], islet antigen 2 antibodies [IA-2A], and The Journal of clinical endocrinology and metabolismApproach to the Patient with MODY-Monogenic Diabetes.PMC7765647R01DK104942P30 DK020595R01 DK104942P30DK020595U54 DK118612DK118612-01Kashyap SRPhilipson LHPantalone KMBroome DTfalseApproach to the Patient with MODY-Monogenic Diabetes.Maturity-onset diabetes of the young, or MODY-monogenic diabetes, is a not-so-rare collection of inherited disorders of non-autoimmune diabetes mellitus that remains insufficiently diagnosed despite increasing awareness. These cases are important to efficiently and accurately diagnose, given the clinical implications of syndromic features, cost-effective treatment regimen, and the potential impact on multiple family members. Proper recognition of the clinical manifestations, family history, and cost-effective lab and genetic testing provide the diagnosis. All patients must undergo a thorough history, physical examination, multigenerational family history, lab evaluation (glycated hemoglobin A1c [HbA1c], glutamic acid decarboxylase antibodies [GADA], islet antigen 2 antibodies [IA-2A], and 2021-01-01T00:00:00Z2021 Jan2025-04-04T03:40:13.128Z2022-02-11T11:59:56.005ZS-EPMC77656473303435010.1210/clinem/dgaa710