{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cuadros M"],"funding":["Aula de Investigación sobre la Leucemia infantil: Héroes contra la Leucemia","Asociación Española Contra el Cáncer (AECC) Foundation","Fundación Benéfica Anticáncer Santa Cándida y San Francisco Javier","Spanish Ministry of Education, Culture and Sports FPU Felowship","La Caixa Foundation Fellowship","Spanish Ministry of Economy and Business","Consejería de Salud de la Junta de Andalucía","Programa Operativo FEDER 2018","Marie Sklodowska Curie Actions Postdoctoral Fellowship"],"pagination":["E3803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7765782"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(12)"],"pubmed_abstract":["Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL dataset"],"journal":["Cancers"],"pubmed_title":["LncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia."],"pmcid":["PMC7765782"],"funding_grant_id":["H2020-MSCA-IF-2018","Pl-0245-2017; CS2016-3","B-CTS-126-UGR18","LCF/BQ/DE15/10360019","Predoctoral Fellowship","Aula2020","LabAECC-2018","SAF2015-67919-R","FPU17/00067; FPU17/01258"],"pubmed_authors":["Cuadros M","Peinado P","Andrades A","Ruiz-Cabello F","Medina PP","Coira IF","Garcia DJ","Alvarez-Perez JC","Jimenez-Velasco A","Camos M","Arenas AM","Rodriguez MI","Balinas-Gavira C"],"additional_accession":[]},"is_claimable":false,"name":"LncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia.","description":"Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL dataset","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-04-28T22:22:27.624Z","creation":"2021-02-20T17:35:35Z"},"accession":"S-EPMC7765782","cross_references":{"pubmed":["33348573"],"doi":["10.3390/cancers12123803"]}}