biostudies-literatureCuadros MAula de Investigación sobre la Leucemia infantil: Héroes contra la LeucemiaAsociación Española Contra el Cáncer (AECC) FoundationFundación Benéfica Anticáncer Santa Cándida y San Francisco JavierSpanish Ministry of Education, Culture and Sports FPU FelowshipLa Caixa Foundation FellowshipSpanish Ministry of Economy and BusinessConsejería de Salud de la Junta de AndalucíaPrograma Operativo FEDER 2018Marie Sklodowska Curie Actions Postdoctoral FellowshipE3803https://www.ebi.ac.uk/biostudies/studies/S-EPMC7765782biostudies-literatureUnknown12(12)Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL datasetCancersLncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia.PMC7765782H2020-MSCA-IF-2018Pl-0245-2017; CS2016-3B-CTS-126-UGR18LCF/BQ/DE15/10360019Predoctoral FellowshipAula2020LabAECC-2018SAF2015-67919-RFPU17/00067; FPU17/01258Cuadros MPeinado PAndrades ARuiz-Cabello FMedina PPCoira IFGarcia DJAlvarez-Perez JCJimenez-Velasco ACamos MArenas AMRodriguez MIBalinas-Gavira CfalseLncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia.Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL dataset2020-01-01T00:00:00Z2020 Dec2026-04-28T22:22:27.624Z2021-02-20T17:35:35ZS-EPMC77657823334857310.3390/cancers12123803