biostudies-literatureNguyen TYTFonds De La Recherche Scientifique - FNRSFondation contre le CancerE4101https://www.ebi.ac.uk/biostudies/studies/S-EPMC7766375biostudies-literatureUnknown9(12)The risk of reseeding malignancy harbored in cryopreserved and transplanted ovarian tissue has been a source of concern. This study aimed to determine the potential relationship between frozen-thawed ovarian tissue transplantation and primary cancer recurrence. Three patients with cerebral primitive neuroectodermal tumors (PNET) were included in this study. One woman gave birth to three healthy babies following reimplantation of her cryopreserved ovarian tissue, but subsequently died due to cancer relapse six years after ovarian tissue transplantation. The second subject died from progressive cancer, while the third is still alive and awaiting reimplantation of her ovarian tissue in due course. Frozen ovarian cortex from all three patients was analyzed and xenotransplanted to immunodeficieJournal of clinical medicineIs Ovarian Tissue Transplantation Safe in Patients with Central Nervous System Primitive Neuroectodermal Tumors?PMC7766375FNRS grant number 5/4/150/5 to Marie-Madeleine Dolmansgrant 2018-042 awarded to Alessandra CamboniFNRS–EOS grant number 30443682 awarded to Marie-Madeleine Dolmans and Thu YT NguyenTélévie grant 7.4590.16 to Rossella MasciangeloFNRS-PDR Convention T.0077.14 to Marie-Madeleine DolmansCamboni AMasciangelo RNguyen TYTDolmans MMDonnez JfalseIs Ovarian Tissue Transplantation Safe in Patients with Central Nervous System Primitive Neuroectodermal Tumors?The risk of reseeding malignancy harbored in cryopreserved and transplanted ovarian tissue has been a source of concern. This study aimed to determine the potential relationship between frozen-thawed ovarian tissue transplantation and primary cancer recurrence. Three patients with cerebral primitive neuroectodermal tumors (PNET) were included in this study. One woman gave birth to three healthy babies following reimplantation of her cryopreserved ovarian tissue, but subsequently died due to cancer relapse six years after ovarian tissue transplantation. The second subject died from progressive cancer, while the third is still alive and awaiting reimplantation of her ovarian tissue in due course. Frozen ovarian cortex from all three patients was analyzed and xenotransplanted to immunodeficie2020-01-01T00:00:00Z2020 Dec2025-04-22T08:38:10.737Z2025-04-05T22:39:12.058ZS-EPMC77663753335325310.3390/jcm9124101