biostudies-literatureUnknown12(12)Catarata MJ<h4>Introduction</h4>The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.<h4>Methods</h4>Genotyping of 52 germline variants from genes of the RAS and hypoxic/angiogenic factors/receptors was performed using MassARRAY iPLEX Gold in a retrospective cohort (<i>n</i> = 167) of advanced NSCLC patients. Validation of the resulting genetic markers was conducted in an independent group (<i>n</i> = 190), matched by clinicopathological characteristics.<h4>Results</h4>MultCancersE3834https://www.ebi.ac.uk/biostudies/studies/S-EPMC7766842biostudies-literatureGermline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies.PMC7766842Oliveira MJKriegsmann MMuley TMeister MRobalo Cordeiro CCatarata MJFrade JGSchneider MAMartins MFMedeiros RThomas MHerth FJFPego ARibeiro RfalseGermline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies.<h4>Introduction</h4>The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.<h4>Methods</h4>Genotyping of 52 germline variants from genes of the RAS and hypoxic/angiogenic factors/receptors was performed using MassARRAY iPLEX Gold in a retrospective cohort (<i>n</i> = 167) of advanced NSCLC patients. Validation of the resulting genetic markers was conducted in an independent group (<i>n</i> = 190), matched by clinicopathological characteristics.<h4>Results</h4>Mult2020-01-01T00:00:00Z2020 Dec2026-04-28T22:22:18.547Z2021-02-20T17:35:34ZS-EPMC77668423335314810.3390/cancers12123834