{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Iimori Y"],"pubmed_abstract":["<h4>Introduction</h4>In-body tissue architecture (iBTA) technology, based on cell-free tissue engineering, can produces collagenous tissues for implantation by subcutaneous embedding a designed mold. The aim of this study was to evaluate the biocompatibility of iBTA-induced \"Biosheet®\" collagenous sheets, as scaffold materials for bladder reconstruction.<h4>Methods</h4>Canine Biosheet® implants were prepared by embedding molds into subcutaneous pouches in beagles for 8 weeks. A part of canine bladder wall was excised (2 × 2 cm) and repaired by patching the same sized autologous Biosheet®. The Biosheet® implants were harvested 4 weeks (n = 1) and 12 weeks (n = 3) after the implantation and evaluated histologically.<h4>Results</h4>No disruption of the patched Biosheet® implants or urinary le"],"journal":["Regenerative therapy"],"pagination":["274-280"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7770416"],"repository":["biostudies-literature"],"pubmed_title":["Urinary bladder reconstruction using autologous collagenous connective tissue membrane \"Biosheet®\" induced by in-body tissue architecture: A pilot study."],"pmcid":["PMC7770416"],"pubmed_authors":["Nagatani K","Nakayama Y","Iwai R","Okamoto M","Iimori Y","Nakata M","Mie K","Akiyoshi H","Inoue Y","Funayama-Iwai M","Nishida H"],"additional_accession":[]},"is_claimable":false,"name":"Urinary bladder reconstruction using autologous collagenous connective tissue membrane \"Biosheet®\" induced by in-body tissue architecture: A pilot study.","description":"<h4>Introduction</h4>In-body tissue architecture (iBTA) technology, based on cell-free tissue engineering, can produces collagenous tissues for implantation by subcutaneous embedding a designed mold. The aim of this study was to evaluate the biocompatibility of iBTA-induced \"Biosheet®\" collagenous sheets, as scaffold materials for bladder reconstruction.<h4>Methods</h4>Canine Biosheet® implants were prepared by embedding molds into subcutaneous pouches in beagles for 8 weeks. A part of canine bladder wall was excised (2 × 2 cm) and repaired by patching the same sized autologous Biosheet®. The Biosheet® implants were harvested 4 weeks (n = 1) and 12 weeks (n = 3) after the implantation and evaluated histologically.<h4>Results</h4>No disruption of the patched Biosheet® implants or urinary le","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-19T08:13:33.276Z","creation":"2021-02-20T20:51:17Z"},"accession":"S-EPMC7770416","cross_references":{"pubmed":["33426229"],"doi":["10.1016/j.reth.2020.10.006"]}}