{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Shao W"],"pubmed_abstract":["Simultaneous photothermal therapy (PTT) and photodynamic therapy (PDT) is beneficial for enhanced cancer therapy due to the synergistic effect. Conventional materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser sources. The emerging monocomponent diketopyrrolopyrrole (DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation, but suffer from low singlet oxygen quantum yield, which severely restricts the therapeutic efficacy. Herein, we report acceptor-oriented molecular design of a donor-acceptor-donor (D-A-D) conjugated small molecule (IID-ThTPA)-based phototheranostic agent, with isoindigo (IID) as selective acceptor and triphenylamine (TPA) as"],"journal":["Nano-micro letters"],"pagination":["147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7770699"],"repository":["biostudies-literature"],"pubmed_title":["Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT."],"pmcid":["PMC7770699"],"pubmed_authors":["Wu J","Wang N","Ling D","Shao W","Li F","Gao J","Ding Q","Yang C"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT.","description":"Simultaneous photothermal therapy (PTT) and photodynamic therapy (PDT) is beneficial for enhanced cancer therapy due to the synergistic effect. Conventional materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser sources. The emerging monocomponent diketopyrrolopyrrole (DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation, but suffer from low singlet oxygen quantum yield, which severely restricts the therapeutic efficacy. Herein, we report acceptor-oriented molecular design of a donor-acceptor-donor (D-A-D) conjugated small molecule (IID-ThTPA)-based phototheranostic agent, with isoindigo (IID) as selective acceptor and triphenylamine (TPA) as","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-05-07T17:12:23.779Z","creation":"2026-04-07T23:04:28.388Z"},"accession":"S-EPMC7770699","cross_references":{"pubmed":["34138129"],"doi":["10.1007/s40820-020-00474-6"]}}