biostudies-literatureUnknown12(1)Shao WSimultaneous photothermal therapy (PTT) and photodynamic therapy (PDT) is beneficial for enhanced cancer therapy due to the synergistic effect. Conventional materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser sources. The emerging monocomponent diketopyrrolopyrrole (DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation, but suffer from low singlet oxygen quantum yield, which severely restricts the therapeutic efficacy. Herein, we report acceptor-oriented molecular design of a donor-acceptor-donor (D-A-D) conjugated small molecule (IID-ThTPA)-based phototheranostic agent, with isoindigo (IID) as selective acceptor and triphenylamine (TPA) asNano-micro letters147https://www.ebi.ac.uk/biostudies/studies/S-EPMC7770699biostudies-literatureMolecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT.PMC7770699Wu JWang NLing DShao WLi FGao JDing QYang CfalseMolecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT.Simultaneous photothermal therapy (PTT) and photodynamic therapy (PDT) is beneficial for enhanced cancer therapy due to the synergistic effect. Conventional materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser sources. The emerging monocomponent diketopyrrolopyrrole (DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation, but suffer from low singlet oxygen quantum yield, which severely restricts the therapeutic efficacy. Herein, we report acceptor-oriented molecular design of a donor-acceptor-donor (D-A-D) conjugated small molecule (IID-ThTPA)-based phototheranostic agent, with isoindigo (IID) as selective acceptor and triphenylamine (TPA) as2020-01-01T00:00:00Z2020 Jul2026-05-07T17:12:23.779Z2026-04-07T23:04:28.388ZS-EPMC77706993413812910.1007/s40820-020-00474-6