biostudies-literatureUnknown29Amaefule CO<h4>Background</h4>Cognitive decline has been found to be associated with gray matter atrophy and disruption of functional neural networks in Alzheimer's disease (AD) in structural and functional imaging (fMRI) studies. Most previous studies have used single test scores of cognitive performance among monocentric cohorts. However, cognitive domain composite scores could be more reliable than single test scores due to the reduction of measurement error. Adopting a multicentric resting state fMRI (rs-fMRI) and cognitive domain approach, we provide a comprehensive description of the structural and functional correlates of the key cognitive domains of AD.<h4>Method</h4>We analyzed MRI, rs-fMRI and cognitive domain score data of 490 participants from an interim baseline release of the multicenteNeuroImage. Clinical102533https://www.ebi.ac.uk/biostudies/studies/S-EPMC7770965biostudies-literatureAssociation between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer's disease spectrum.PMC7770965Duzel ESpottke AAmaefule COGlanz WSchneider AJanowitz DPeters OPriller JLaske CDechent PDyrba MPolcher ATeipel SJPreis LSpruth EJHaynes JDJessen FWagner MWiltfang JBurger KScheffler KFliessbach KDobisch LAltenstein SRudolph JKilimann IMetzger CDMunk MWolfsgruber SErtl-Wagner BMeiberth DIncesoy EIBartels CfalseAssociation between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer's disease spectrum.<h4>Background</h4>Cognitive decline has been found to be associated with gray matter atrophy and disruption of functional neural networks in Alzheimer's disease (AD) in structural and functional imaging (fMRI) studies. Most previous studies have used single test scores of cognitive performance among monocentric cohorts. However, cognitive domain composite scores could be more reliable than single test scores due to the reduction of measurement error. Adopting a multicentric resting state fMRI (rs-fMRI) and cognitive domain approach, we provide a comprehensive description of the structural and functional correlates of the key cognitive domains of AD.<h4>Method</h4>We analyzed MRI, rs-fMRI and cognitive domain score data of 490 participants from an interim baseline release of the multicente2021-01-01T00:00:00Z20212025-06-01T02:32:57.275Z2025-06-01T02:32:57.275ZS-EPMC77709653336001810.1016/j.nicl.2020.102533