{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guillen-Guio B"],"funding":["Instituto de Salud Carlos III","NHLBI NIH HHS","National Institutes of Health","European Regional Development Fund"],"pagination":["258-266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7772505"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(3)"],"pubmed_abstract":["<h4>Background</h4>Acute respiratory distress syndrome (ARDS) is a lung inflammatory process caused mainly by sepsis. Most previous studies that identified genetic risks for ARDS focused on candidates with biological relevance. We aimed to identify novel genetic variants associated with ARDS susceptibility and to provide complementary functional evidence of their effect in gene regulation.<h4>Methods</h4>We did a case-control genome-wide association study (GWAS) of 1935 European individuals, using patients with sepsis-associated ARDS as cases and patients with sepsis without ARDS as controls. The discovery stage included 672 patients admitted into a network of Spanish intensive care units between January, 2002, and January, 2017. The replication stage comprised 1345 individuals from two in"],"journal":["The Lancet. Respiratory medicine"],"pubmed_title":["Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study."],"pmcid":["PMC7772505"],"funding_grant_id":["CB06/06/1088","R01 HL137915","R01 HL130796","PI16/00759","PI14/00844","CN104204808A","PI10/0393","PI16/00049","R01 HL137006","OA17/008","HL137006","PI17/00610","HL137915","EP2780719","FI17/00177","EP2592421"],"pubmed_authors":["Kiehntopf M","Guillen-Guio B","Jones TK","Sole-Violan J","Ambros A","Flores C","Hou PC","Anon JM","Brunkhorst FM","Villar J","Noth I","Ma SF","Carriedo D","Ittner CA","Lorenzo-Salazar JM","Jou J","Blanco J","Corrales A","Martin MM","Rodriguez-Gallego C","Lorente L","Scholz M","Meyer NJ","Reilly JP","Dominguez D","Muriel A","Scherag A","Garcia-Laorden MI","Hernandez-Beeftink T","Espinosa E","Schoneweck F","Feng R"],"additional_accession":[]},"is_claimable":false,"name":"Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study.","description":"<h4>Background</h4>Acute respiratory distress syndrome (ARDS) is a lung inflammatory process caused mainly by sepsis. Most previous studies that identified genetic risks for ARDS focused on candidates with biological relevance. We aimed to identify novel genetic variants associated with ARDS susceptibility and to provide complementary functional evidence of their effect in gene regulation.<h4>Methods</h4>We did a case-control genome-wide association study (GWAS) of 1935 European individuals, using patients with sepsis-associated ARDS as cases and patients with sepsis without ARDS as controls. The discovery stage included 672 patients admitted into a network of Spanish intensive care units between January, 2002, and January, 2017. The replication stage comprised 1345 individuals from two in","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-05-01T12:43:18.298Z","creation":"2021-03-03T08:16:24Z"},"accession":"S-EPMC7772505","cross_references":{"pubmed":["31982041"],"doi":["10.1016/s2213-2600(19)30368-6","10.1016/S2213-2600(19)30368-6"]}}