biostudies-literatureUnknown9(12)Li JSDiabetic retinopathy (DR), the most common microvascular complication of diabetes and leading cause of visual impairment in adults worldwide, is suggested to be linked to abnormal lipid metabolism. The present study aims to comprehensively investigate the relationship between n-6 polyunsaturated fatty acids (PUFAs) and DR. This was a propensity score matching based case-control study, including 69 pairs of DR patients and type 2 diabetic patients without DR with mean age of 56.7 ± 9.2 years. Five n-6 PUFAs were determined by UPLC-ESI-MS/MS system. Principle component regression (PCR) and multiple conditional logistic regression models were used to investigate the association of DR risk with n-6 PUFAs depending on independent training and testing sets, respectively. According to locally weiEndocrine connections1191-1201https://www.ebi.ac.uk/biostudies/studies/S-EPMC7774753biostudies-literatureAssociation of n-6 PUFAs with the risk of diabetic retinopathy in diabetic patients.PMC7774753Guo CNPeng FLi JSHou XQWang TZheng CMao GYZhao SZWei YPZuo JJLi HHLan YfalseAssociation of n-6 PUFAs with the risk of diabetic retinopathy in diabetic patients.Diabetic retinopathy (DR), the most common microvascular complication of diabetes and leading cause of visual impairment in adults worldwide, is suggested to be linked to abnormal lipid metabolism. The present study aims to comprehensively investigate the relationship between n-6 polyunsaturated fatty acids (PUFAs) and DR. This was a propensity score matching based case-control study, including 69 pairs of DR patients and type 2 diabetic patients without DR with mean age of 56.7 ± 9.2 years. Five n-6 PUFAs were determined by UPLC-ESI-MS/MS system. Principle component regression (PCR) and multiple conditional logistic regression models were used to investigate the association of DR risk with n-6 PUFAs depending on independent training and testing sets, respectively. According to locally wei2020-01-01T00:00:00Z2020 Dec2025-04-04T23:47:17.588Z2021-02-20T18:43:56ZS-EPMC77747533311282610.1530/EC-20-0370