{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bedimo RJ"],"funding":["NCATS NIH HHS","NIAAA NIH HHS","NCI NIH HHS"],"pagination":["325-334"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7775280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(2)"],"pubmed_abstract":["<h4>Objective</h4>To determine whether statin exposure is associated with decreased cancer and mortality risk among persons with HIV (PWH) and uninfected persons. Statins appear to have immunomodulatory and anti-inflammatory effects and may reduce cancer risk, particularly among PWH as they experience chronic inflammation and immune activation.<h4>Design</h4>Propensity score-matched cohort of statin-exposed and unexposed patients from 2002 to 2017 in the Veterans Aging Cohort Study (VACS), a large cohort with cancer registry linkage and detailed pharmacy data.<h4>Methods</h4>We calculated Cox regression hazard ratios (HRs) and 95% confidence intervals (CI) associated with statin use for all cancers, microbial cancers (associated with bacterial or oncovirus coinfection), nonmicrobial cancer"],"journal":["AIDS (London, England)"],"pubmed_title":["Statin exposure and risk of cancer in people with and without HIV infection."],"pmcid":["PMC7775280"],"funding_grant_id":["U01 AA020790","U01 AA013566","U01 AA026224","UL1 TR001863","R01 CA210806","U24 AA020794","R01 CA206465"],"pubmed_authors":["Rodriguez-Barradas MC","Bedimo RJ","Rentsch CT","Goetz MB","Justice AC","Tate JP","Gibert C","Park LS","Sigel K","Shebl FM","Brown ST","Butt AA","Crothers K"],"additional_accession":[]},"is_claimable":false,"name":"Statin exposure and risk of cancer in people with and without HIV infection.","description":"<h4>Objective</h4>To determine whether statin exposure is associated with decreased cancer and mortality risk among persons with HIV (PWH) and uninfected persons. Statins appear to have immunomodulatory and anti-inflammatory effects and may reduce cancer risk, particularly among PWH as they experience chronic inflammation and immune activation.<h4>Design</h4>Propensity score-matched cohort of statin-exposed and unexposed patients from 2002 to 2017 in the Veterans Aging Cohort Study (VACS), a large cohort with cancer registry linkage and detailed pharmacy data.<h4>Methods</h4>We calculated Cox regression hazard ratios (HRs) and 95% confidence intervals (CI) associated with statin use for all cancers, microbial cancers (associated with bacterial or oncovirus coinfection), nonmicrobial cancer","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-18T15:10:36.35Z","creation":"2022-02-11T15:50:23.933Z"},"accession":"S-EPMC7775280","cross_references":{"pubmed":["33181533"],"doi":["10.1097/qad.0000000000002748","10.1097/QAD.0000000000002748"]}}