biostudies-literatureBedimo RJNCATS NIH HHSNIAAA NIH HHSNCI NIH HHS325-334https://www.ebi.ac.uk/biostudies/studies/S-EPMC7775280biostudies-literatureUnknown35(2)<h4>Objective</h4>To determine whether statin exposure is associated with decreased cancer and mortality risk among persons with HIV (PWH) and uninfected persons. Statins appear to have immunomodulatory and anti-inflammatory effects and may reduce cancer risk, particularly among PWH as they experience chronic inflammation and immune activation.<h4>Design</h4>Propensity score-matched cohort of statin-exposed and unexposed patients from 2002 to 2017 in the Veterans Aging Cohort Study (VACS), a large cohort with cancer registry linkage and detailed pharmacy data.<h4>Methods</h4>We calculated Cox regression hazard ratios (HRs) and 95% confidence intervals (CI) associated with statin use for all cancers, microbial cancers (associated with bacterial or oncovirus coinfection), nonmicrobial cancerAIDS (London, England)Statin exposure and risk of cancer in people with and without HIV infection.PMC7775280U01 AA020790U01 AA013566U01 AA026224UL1 TR001863R01 CA210806U24 AA020794R01 CA206465Rodriguez-Barradas MCBedimo RJRentsch CTGoetz MBJustice ACTate JPGibert CPark LSSigel KShebl FMBrown STButt AACrothers KfalseStatin exposure and risk of cancer in people with and without HIV infection.<h4>Objective</h4>To determine whether statin exposure is associated with decreased cancer and mortality risk among persons with HIV (PWH) and uninfected persons. Statins appear to have immunomodulatory and anti-inflammatory effects and may reduce cancer risk, particularly among PWH as they experience chronic inflammation and immune activation.<h4>Design</h4>Propensity score-matched cohort of statin-exposed and unexposed patients from 2002 to 2017 in the Veterans Aging Cohort Study (VACS), a large cohort with cancer registry linkage and detailed pharmacy data.<h4>Methods</h4>We calculated Cox regression hazard ratios (HRs) and 95% confidence intervals (CI) associated with statin use for all cancers, microbial cancers (associated with bacterial or oncovirus coinfection), nonmicrobial cancer2021-01-01T00:00:00Z2021 Feb2025-04-18T15:10:36.35Z2022-02-11T15:50:23.933ZS-EPMC77752803318153310.1097/qad.000000000000274810.1097/QAD.0000000000002748