biostudies-literatureUnknown8Bardanzellu F<b>Introduction:</b> In premature neonates, the persistence of hemodynamically significant ductus arteriosus (hsPDA) can be associated with short- and long-term consequences, impairing their outcome. The correct strategy of management for such condition is under debate, especially regarding contraindications and/or side effects. In recent years, metabolomics was applied to several perinatal, pediatric, and adult conditions to investigate potential biomarkers of disease, which have become useful for early diagnosis and/or therapeutic management. <b>Aim of the Study:</b> The main purpose of our exploratory study was to asses, through ¹H-NMR metabolomics analysis of urinary samples at birth, possible metabolic pathways differentiating, with a significant predictive power, those preFrontiers in pediatrics613749https://www.ebi.ac.uk/biostudies/studies/S-EPMC7779766biostudies-literatureEarly Urinary Metabolomics in Patent Ductus Arteriosus Anticipates the Fate: Preliminary Data.PMC7779766Atzei AFanos VBardanzellu FNeroni PPiras CfalseEarly Urinary Metabolomics in Patent Ductus Arteriosus Anticipates the Fate: Preliminary Data.<b>Introduction:</b> In premature neonates, the persistence of hemodynamically significant ductus arteriosus (hsPDA) can be associated with short- and long-term consequences, impairing their outcome. The correct strategy of management for such condition is under debate, especially regarding contraindications and/or side effects. In recent years, metabolomics was applied to several perinatal, pediatric, and adult conditions to investigate potential biomarkers of disease, which have become useful for early diagnosis and/or therapeutic management. <b>Aim of the Study:</b> The main purpose of our exploratory study was to asses, through ¹H-NMR metabolomics analysis of urinary samples at birth, possible metabolic pathways differentiating, with a significant predictive power, those pre2020-01-01T00:00:00Z20202026-07-09T10:58:48.099Z2026-07-09T10:35:05.151ZS-EPMC77797663340926210.3389/fped.2020.613749