biostudies-literatureLeistner DMAmerican Heart AssociationDeutsche Stiftung für HerzforschungNational Heart, Lung, and Blood InstituteBerlin Institute of HealthNHLBI NIH HHSGerman Centre for Cardiovascular ResearchAbbott Vascular3549-3560https://www.ebi.ac.uk/biostudies/studies/S-EPMC7780480biostudies-literatureUnknown41(37)<h4>Aims</h4>Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by coronary plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared with ACS caused by plaque rupture (RFC-ACS) remain largely undefined. The prospective translational OPTICO-ACS study programme investigates for the first time the microenvironment of ACS-causing culprit lesions (CL) with intact fibrous cap by molecular high-resolution intracoronary imaging and simultaneous local immunological phenotyping.<h4>Methods and results</h4>The CL of 170 consecutive ACS patients were investigated by optical coherence tomography (OCT) and simultaneous immunophenotyping by flow cytometric analysis as well as by effector molecule concentration measuEuropean heart journalDifferential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.PMC77804801R01HL13489281Z2100202R01 HL13489218CSA34080399Landmesser UKia SSteiner JKMueller DNFlores EStahli BERiedel MRai HRauch-Krohnert UAbdelwahed YSKrankel NLeistner DMMochmann HCVolk HDSieronski LKlotsche JStrassler EHaghikia AMeteva DLauten AFrohlich GLibby PDirks FJoner MSkurk CSeppelt CfalseDifferential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.<h4>Aims</h4>Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by coronary plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared with ACS caused by plaque rupture (RFC-ACS) remain largely undefined. The prospective translational OPTICO-ACS study programme investigates for the first time the microenvironment of ACS-causing culprit lesions (CL) with intact fibrous cap by molecular high-resolution intracoronary imaging and simultaneous local immunological phenotyping.<h4>Methods and results</h4>The CL of 170 consecutive ACS patients were investigated by optical coherence tomography (OCT) and simultaneous immunophenotyping by flow cytometric analysis as well as by effector molecule concentration measu2020-01-01T00:00:00Z2020 Oct2026-04-07T16:13:48.962Z2025-04-06T00:00:57.896ZS-EPMC77804803308000310.1093/eurheartj/ehaa703