{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kolmert J"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["37-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7781128"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["203(1)"],"pubmed_abstract":["<b>Rationale:</b> New approaches are needed to guide personalized treatment of asthma.<b>Objectives:</b> To test if urinary eicosanoid metabolites can direct asthma phenotyping.<b>Methods:</b> Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes) study including 86 adults with mild-to-moderate asthma (MMA), 411 with severe asthma (SA), and 100 healthy control participants. Validation was performed internally in 302 participants with SA followed up after 12-18 months and externally in 95 adolescents with asthma.<b>Measurement and Main Results:</b> Metabolite concentrations in healthy control participants were unrelated to age, body mass index, a"],"journal":["American journal of respiratory and critical care medicine"],"pubmed_title":["Urinary Leukotriene E&lt;sub&gt;4&lt;/sub&gt; and Prostaglandin D&lt;sub&gt;2&lt;/sub&gt; Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study."],"pmcid":["PMC7781128"],"funding_grant_id":["NIHR200199","MR/N005953/1"],"pubmed_authors":["Hedlin G","D'Amico A","Boedigheimer MJ","Guo Y","James A","Gomez C","Cunoosamy D","Pratico G","Rowe A","Skipp PJ","Caruso M","Ahmed H","Pavlidis S","Postle A","Bonnelykke K","Adcock IM","Brinkman P","Erzen D","Pahus L","Chanez P","Bucchioni E","Sandstrom T","Meiser A","Schofield JPR","Fleming LJ","Lefaudeux D","Djukanovic R","Masefield S","Matthews JG","Frey U","van Geest M","Middelveld RJM","Singer F","Krug N","Bood J","Bigler J","Wheelock AM","Alving K","Burg D","Murray CS","Ostling J","Baribaud F","Vissing NH","Mores N","Hashimoto S","Powel P","Higenbottam T","Wagers SS","Thornton B","Knox AJ","Fichtner K","Thorngren JO","van Aalderen WM","Bisgaard H","Howarth P","Bush A","Behndig A","Smicker M","Weiszhart Z","Roberts A","Fitch N","Kolmert J","Ericsson M","Dahlen SE","De Meulder B","Mikus M","Brandsma J","Formaggio E","Roberts G","Fowler SJ","Holweg CTJ","Manta A","Mazein A","Gahlemann M","Miralpeix M","Seibold W","Wheelock CE","Musial J","Wilson SJ","Sousa AR","Sterk PJ","Lutter R","Rao N","Sun K","Bates S","PuigValls M","Myles D","Corfield J","Geiser T","Auffray C","Montuschi P","Knowles RG","Nordlund B","Dahlen B","Chung KF","Konradsen JR","Bansal AT","Sigmund R","Loza MJ","Pandis I","Haughney J","Bel EH","Billing B","Wagener AH","Erpenbeck VJ","Horvath I","Balgoma D","Goss V","Hekking PW","Lazarinis N","Hohlfeld JM","Sjodin M","Selby A","Bakke PS","Chaiboonchoe A","Uddin M","Vestbo J","Sanak M","Riley JH","U-BIOPRED Study Group, on behalf of the U-BIOPRED Study Group","Shaw DE","Compton CH"],"additional_accession":[]},"is_claimable":false,"name":"Urinary Leukotriene E&lt;sub&gt;4&lt;/sub&gt; and Prostaglandin D&lt;sub&gt;2&lt;/sub&gt; Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study.","description":"<b>Rationale:</b> New approaches are needed to guide personalized treatment of asthma.<b>Objectives:</b> To test if urinary eicosanoid metabolites can direct asthma phenotyping.<b>Methods:</b> Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes) study including 86 adults with mild-to-moderate asthma (MMA), 411 with severe asthma (SA), and 100 healthy control participants. Validation was performed internally in 302 participants with SA followed up after 12-18 months and externally in 95 adolescents with asthma.<b>Measurement and Main Results:</b> Metabolite concentrations in healthy control participants were unrelated to age, body mass index, a","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-06-02T16:19:45.32Z","creation":"2022-02-09T17:36:40.447Z"},"accession":"S-EPMC7781128","cross_references":{"pubmed":["32667261"],"doi":["10.1164/rccm.201909-1869OC"]}}