biostudies-literatureTopalovic UMcKnight Endowment Fund for NeuroscienceW. M. Keck FoundationNINDS NIH HHSNational Institutes of Health322-334.e9https://www.ebi.ac.uk/biostudies/studies/S-EPMC7785319biostudies-literatureUnknown108(2)Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, andNeuronWireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.PMC7785319U01 NS117838U01 NS103802T32 NS058280Hasulak NRSuthana NAghajan ZMRao VRHiller SEliashiv DChristov-Moore LTopalovic UVillaroman DFried IInman CSStangl MWishard TJFields TAfalseWireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and2020-01-01T00:00:00Z2020 Oct2026-05-03T10:11:09.968Z2025-04-04T19:50:27.551ZS-EPMC77853193294674410.1016/j.neuron.2020.08.021