biostudies-literatureSuen JLMinistry of Science and TechnologyShenzhen Peacock PlanKaohsiung Medical UniversityCenter of Excellence for Environmental Medicine, Kaohsiung Medical UniversityNational Health Research InstitutesNCI NIH HHSHSRD VA603831https://www.ebi.ac.uk/biostudies/studies/S-EPMC7786300biostudies-literatureUnknown11The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its underlying mechanism remain unknown. This study explored the transgenerational mechanism of DEHP on allergic asthma and dendritic cell (DC) homeostasis through epigenetic modification. In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the <i>insulin-like growth factor 2 receptor</i> (<i>Igf2r</i>), concomitant with enhanced Igf2r expression and increased apoptosis prominently in CD8α⁺ DCs uponFrontiers in immunologyEnvironmental Factor-Mediated Transgenerational Inheritance of <i>Igf2r</i> Hypomethylation and Pulmonary Allergic Response <i>via</i> Targeting Dendritic Cells.PMC7786300P30 CA016058R50 CA211524CDA 10-014MOST 105-2320-B-037-015, MOST 106-2314-B-037-072, MOST 107-2314-B-037-003, MOST 108-2314-B-037-001, MOST 108-2320-B-037-010The Talent Plan (105KMUOR04), KMU-TC108A01KMU-TP104A05, KMU-TP105A02NHRI-102A1-PDCO-03010201, EOPP10-014, EOSP07-014Wang CJKuo FCLi YHLee CLTran MYan PSWu MTSuen JLWu CFHung CHHuang SKChan MWYWu TTfalseEnvironmental Factor-Mediated Transgenerational Inheritance of <i>Igf2r</i> Hypomethylation and Pulmonary Allergic Response <i>via</i> Targeting Dendritic Cells.The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its underlying mechanism remain unknown. This study explored the transgenerational mechanism of DEHP on allergic asthma and dendritic cell (DC) homeostasis through epigenetic modification. In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the <i>insulin-like growth factor 2 receptor</i> (<i>Igf2r</i>), concomitant with enhanced Igf2r expression and increased apoptosis prominently in CD8α⁺ DCs upon2020-01-01T00:00:00Z20202026-05-02T06:36:11.703Z2025-04-04T07:16:30.403ZS-EPMC77863003342485010.3389/fimmu.2020.603831