biostudies-literatureUnknown11(1)Dribin TE<h4>Introduction</h4>There remain significant knowledge gaps about the management and outcomes of children with anaphylaxis. These gaps have led to practice variation regarding decisions to hospitalise children and length of observation periods following treatment with epinephrine. The objectives of this multicentre study are to (1) determine the prevalence of and risk factors for severe, persistent, refractory and biphasic anaphylaxis, as well as persistent and biphasic non-anaphylactic reactions; (2) derive and validate prediction models for emergency department (ED) discharge; and (3) determine data-driven lengths of ED and inpatient observation prior to discharge to home based on initial reaction severity.<h4>Methods and analysis</h4>The study is being conducted through the Pediatric EBMJ opene037341https://www.ebi.ac.uk/biostudies/studies/S-EPMC7786808biostudies-literaturePEMCRC anaphylaxis study protocol: a multicentre cohort study to derive and validate clinical decision models for the emergency department management of children with anaphylaxis.PMC7786808Brousseau DCWitry JDribin TENeuman MIMistry RDViswanathan SVyles DZhang NDayan PSSchnadower DMichelson KABoyd SfalsePEMCRC anaphylaxis study protocol: a multicentre cohort study to derive and validate clinical decision models for the emergency department management of children with anaphylaxis.<h4>Introduction</h4>There remain significant knowledge gaps about the management and outcomes of children with anaphylaxis. These gaps have led to practice variation regarding decisions to hospitalise children and length of observation periods following treatment with epinephrine. The objectives of this multicentre study are to (1) determine the prevalence of and risk factors for severe, persistent, refractory and biphasic anaphylaxis, as well as persistent and biphasic non-anaphylactic reactions; (2) derive and validate prediction models for emergency department (ED) discharge; and (3) determine data-driven lengths of ED and inpatient observation prior to discharge to home based on initial reaction severity.<h4>Methods and analysis</h4>The study is being conducted through the Pediatric E2021-01-01T00:00:00Z2021 Jan2026-07-16T04:45:45.649Z2021-02-20T22:04:01ZS-EPMC77868083340240210.1136/bmjopen-2020-037341