{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ly Pham L"],"funding":["Intramural EPA"],"pagination":["1-100126"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7787987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(August 2020)"],"pubmed_abstract":["New approach methodologies (NAMs) for chemical hazard assessment are often evaluated via comparison to animal studies; however, variability in animal study data limits NAM accuracy. The US EPA Toxicity Reference Database (ToxRefDB) enables consideration of variability in effect levels, including the lowest effect level (LEL) for a treatment-related effect and the lowest observable adverse effect level (LOAEL) defined by expert review, from subacute, subchronic, chronic, multi-generation reproductive, and developmental toxicity studies. The objectives of this work were to quantify the variance within systemic LEL and LOAEL values, defined as potency values for effects in adult or parental animals only, and to estimate the upper limit of NAM prediction accuracy. Multiple linear regression (M"],"journal":["Computational toxicology (Amsterdam, Netherlands)"],"pubmed_title":["Variability in <i>in vivo</i> studies: Defining the upper limit of performance for predictions of systemic effect levels."],"pmcid":["PMC7787987"],"funding_grant_id":["EPA999999"],"pubmed_authors":["Ly Pham L","Pradeep P","Thomas R","Martin MT","Judson R","Paul Friedman K","Setzer RW","Watford S"],"additional_accession":[]},"is_claimable":false,"name":"Variability in <i>in vivo</i> studies: Defining the upper limit of performance for predictions of systemic effect levels.","description":"New approach methodologies (NAMs) for chemical hazard assessment are often evaluated via comparison to animal studies; however, variability in animal study data limits NAM accuracy. The US EPA Toxicity Reference Database (ToxRefDB) enables consideration of variability in effect levels, including the lowest effect level (LEL) for a treatment-related effect and the lowest observable adverse effect level (LOAEL) defined by expert review, from subacute, subchronic, chronic, multi-generation reproductive, and developmental toxicity studies. The objectives of this work were to quantify the variance within systemic LEL and LOAEL values, defined as potency values for effects in adult or parental animals only, and to estimate the upper limit of NAM prediction accuracy. Multiple linear regression (M","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-20T03:40:31.341Z","creation":"2022-02-11T00:57:55.387Z"},"accession":"S-EPMC7787987","cross_references":{"pubmed":["33426408"],"doi":["10.1016/j.comtox.2020.100126"]}}