{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Avery SN"],"funding":["NCATS NIH HHS","Vanderbilt Institute for Clinical and Translational Research","NIMH NIH HHS"],"pagination":["20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7791099"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Neural habituation, the decrease in brain response to repeated stimuli, is a fundamental, highly conserved mechanism that acts as an essential filter for our complex sensory environment. Convergent evidence indicates neural habituation is disrupted in both early and chronic stages of schizophrenia, with deficits co-occurring in brain regions that show inhibitory dysfunction. As inhibitory deficits have been proposed to contribute to the onset and progression of illness, habituation may be an important treatment target. However, a crucial first step is clarifying whether habituation deficits progress with illness. In the present study, we measured neural habituation in 138 participants (70 early psychosis patients (<2 years of illness), 68 healthy controls), with 108 participants assessed l"],"journal":["Translational psychiatry"],"pubmed_title":["Stable habituation deficits in the early stage of psychosis: a 2-year follow-up study."],"pmcid":["PMC7791099"],"funding_grant_id":["R01 MH070560","UL1 TR000445"],"pubmed_authors":["Armstrong K","Avery SN","McHugo M","Blackford JU","Heckers S","Woodward ND"],"additional_accession":[]},"is_claimable":false,"name":"Stable habituation deficits in the early stage of psychosis: a 2-year follow-up study.","description":"Neural habituation, the decrease in brain response to repeated stimuli, is a fundamental, highly conserved mechanism that acts as an essential filter for our complex sensory environment. Convergent evidence indicates neural habituation is disrupted in both early and chronic stages of schizophrenia, with deficits co-occurring in brain regions that show inhibitory dysfunction. As inhibitory deficits have been proposed to contribute to the onset and progression of illness, habituation may be an important treatment target. However, a crucial first step is clarifying whether habituation deficits progress with illness. In the present study, we measured neural habituation in 138 participants (70 early psychosis patients (<2 years of illness), 68 healthy controls), with 108 participants assessed l","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-25T20:48:34.732Z","creation":"2025-04-06T08:26:12.965Z"},"accession":"S-EPMC7791099","cross_references":{"pubmed":["33414431"],"doi":["10.1038/s41398-020-01167-9"]}}