{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(23)"],"submitter":["Li H"],"pubmed_abstract":["Cardiovascular complications are the leading causes of diabetes-related morbidity and mortality. The high incidence and poor prognosis of heart failure in diabetic patients have been associated, in part, to the presence of an underlying cardiomyopathy characterized by cardiac hypertrophy, cardiomyocytes apoptosis, and fibrosis. It has been unclear about the mechanism that connects diabetes mellitus to the development of cardiovascular dysfunction. Micro(mi)RNAs represent a class of small, 18- to 28-nucleotide-long, non-coding RNA molecules. MiRNAs typically suppress gene expression at the post-transcriptional levels by binding directly to the 3'-UTR of the target mRNAs in the cytoplasm. Interestingly, recent studies suggest that miRNAs may also regulate gene expression in a positive manner."],"journal":["Annals of translational medicine"],"pagination":["1602"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7791206"],"repository":["biostudies-literature"],"pubmed_title":["Subcellular microRNAs in diabetic cardiomyopathy."],"pmcid":["PMC7791206"],"pubmed_authors":["Li H","Wang DW","Fan J","Chen C"],"additional_accession":[]},"is_claimable":false,"name":"Subcellular microRNAs in diabetic cardiomyopathy.","description":"Cardiovascular complications are the leading causes of diabetes-related morbidity and mortality. The high incidence and poor prognosis of heart failure in diabetic patients have been associated, in part, to the presence of an underlying cardiomyopathy characterized by cardiac hypertrophy, cardiomyocytes apoptosis, and fibrosis. It has been unclear about the mechanism that connects diabetes mellitus to the development of cardiovascular dysfunction. Micro(mi)RNAs represent a class of small, 18- to 28-nucleotide-long, non-coding RNA molecules. MiRNAs typically suppress gene expression at the post-transcriptional levels by binding directly to the 3'-UTR of the target mRNAs in the cytoplasm. Interestingly, recent studies suggest that miRNAs may also regulate gene expression in a positive manner.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-05T16:10:29.325Z","creation":"2025-04-05T16:10:29.325Z"},"accession":"S-EPMC7791206","cross_references":{"pubmed":["33437801"],"doi":["10.21037/atm-20-2205"]}}