{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(23)"],"submitter":["Huang Y"],"pubmed_abstract":["<h4>Background</h4>Transmethylation reactions play an important role on lymphocyte activation and function. S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitors prevent the feedback of transmethylation reactions by S-adenosyl-L-homocysteine (SAH) accumulation, a competitive antagonist of S-adenosylmethionine (SAM)-dependent methyltransferases. However, the role of SAH in solid organ transplantation is currently unclear.<h4>Methods</h4>A murine model of cardiac transplantation (BALB/C to C57B/6) was established to assess allograft survival, histology, and T cell infiltration. The reversible SAHH inhibitor, DZ2002, and irreversible SAHH inhibitor, adenosine dialdehyde (AdOx), were used to assess their immunosuppressive effects in murine cardiac transplantation, compared with mice with DMSO."],"journal":["Annals of translational medicine"],"pagination":["1582"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7791210"],"repository":["biostudies-literature"],"pubmed_title":["Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4<sup>+</sup> T-cell activation in a mouse heart transplantation model."],"pmcid":["PMC7791210"],"pubmed_authors":["Ding X","Huang Y","Chen J","Hu Z","Wang S","Wu C","Du X","Wang G"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4<sup>+</sup> T-cell activation in a mouse heart transplantation model.","description":"<h4>Background</h4>Transmethylation reactions play an important role on lymphocyte activation and function. S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitors prevent the feedback of transmethylation reactions by S-adenosyl-L-homocysteine (SAH) accumulation, a competitive antagonist of S-adenosylmethionine (SAM)-dependent methyltransferases. However, the role of SAH in solid organ transplantation is currently unclear.<h4>Methods</h4>A murine model of cardiac transplantation (BALB/C to C57B/6) was established to assess allograft survival, histology, and T cell infiltration. The reversible SAHH inhibitor, DZ2002, and irreversible SAHH inhibitor, adenosine dialdehyde (AdOx), were used to assess their immunosuppressive effects in murine cardiac transplantation, compared with mice with DMSO.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-05T16:07:06.05Z","creation":"2025-04-05T16:07:06.05Z"},"accession":"S-EPMC7791210","cross_references":{"pubmed":["33437781"],"doi":["10.21037/atm-20-2899"]}}