biostudies-literatureUnknown8(23)Han F<h4>Background</h4>Rapid economic growth and increasing lifespan have contributed to an increasing burden of chronic non-communicable diseases in China. Population-based studies focusing on cardiovascular disease and age-related brain changes, with extensive clinical, genetic, and imaging data as well as a comprehensive evaluation of brain function are lacking in China. The Shunyi cohort study aimed to investigate the determinants and consequences of cardiovascular disease and age-related brain alterations among individuals residing in a rural area of Beijing.<h4>Methods</h4>This prospective, community-based study included individuals aged 35 years and older living in five villages in Shunyi, a rural district located 20 miles from urban Beijing. A total of 1,586 individuals were enrolled bAnnals of translational medicine1579https://www.ebi.ac.uk/biostudies/studies/S-EPMC7791225biostudies-literatureDesign of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study.PMC7791225Ni JZhu YCZhou LXCui LYZhai FFYao MYang MLiu YTZhang SYJin ZYDai QWu WXue HDLi MLHan FfalseDesign of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study.<h4>Background</h4>Rapid economic growth and increasing lifespan have contributed to an increasing burden of chronic non-communicable diseases in China. Population-based studies focusing on cardiovascular disease and age-related brain changes, with extensive clinical, genetic, and imaging data as well as a comprehensive evaluation of brain function are lacking in China. The Shunyi cohort study aimed to investigate the determinants and consequences of cardiovascular disease and age-related brain alterations among individuals residing in a rural area of Beijing.<h4>Methods</h4>This prospective, community-based study included individuals aged 35 years and older living in five villages in Shunyi, a rural district located 20 miles from urban Beijing. A total of 1,586 individuals were enrolled b2020-01-01T00:00:00Z2020 Dec2025-04-05T16:11:18.959Z2025-04-05T16:11:18.959ZS-EPMC77912253343777810.21037/atm-20-4195