{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(23)"],"submitter":["Fan KJ"],"pubmed_abstract":["Background
Metformin (MF) is a widely used biguanide oral hypoglycemic agent, which has obvious anti-inflammatory and immunomodulatory effects. However, the mechanism of MF on rheumatoid arthritis (RA) remains uncertain. In this study, we investigated the therapeutic effects of MF on collagen-induced arthritis (CIA).Methods
CIA was induced in rats by intradermal injection of a mixture of bovine type II collagen and incomplete Freund's adjuvant (IFA) on day 0 and day 7 through the base of the tail. Intraperitoneal injection of MF (100 mg/kg) was given every 3 days, from day 14 for 3 weeks. The effects of MF on arthritis-induced systemic inflammation and synovitis were studied by pathological analysis of the knee joint and serological examination of peripheral blood in CIA ra"],"journal":["Annals of translational medicine"],"pagination":["1565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7791269"],"repository":["biostudies-literature"],"pubmed_title":["Metformin inhibits inflammation and bone destruction in collagen-induced arthritis in rats."],"pmcid":["PMC7791269"],"pubmed_authors":["Fan KJ","Zhao FT","Wu J","Wang TY","Xu BX","Wang QS"],"additional_accession":[]},"is_claimable":false,"name":"Metformin inhibits inflammation and bone destruction in collagen-induced arthritis in rats.","description":"Background
Metformin (MF) is a widely used biguanide oral hypoglycemic agent, which has obvious anti-inflammatory and immunomodulatory effects. However, the mechanism of MF on rheumatoid arthritis (RA) remains uncertain. In this study, we investigated the therapeutic effects of MF on collagen-induced arthritis (CIA).Methods
CIA was induced in rats by intradermal injection of a mixture of bovine type II collagen and incomplete Freund's adjuvant (IFA) on day 0 and day 7 through the base of the tail. Intraperitoneal injection of MF (100 mg/kg) was given every 3 days, from day 14 for 3 weeks. The effects of MF on arthritis-induced systemic inflammation and synovitis were studied by pathological analysis of the knee joint and serological examination of peripheral blood in CIA ra","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-05T16:07:19.649Z","creation":"2025-04-05T16:07:19.649Z"},"accession":"S-EPMC7791269","cross_references":{"pubmed":["33437764"],"doi":["10.21037/atm-20-3042"]}}