biostudies-literatureUnknown8(23)Fan KJ<h4>Background</h4>Metformin (MF) is a widely used biguanide oral hypoglycemic agent, which has obvious anti-inflammatory and immunomodulatory effects. However, the mechanism of MF on rheumatoid arthritis (RA) remains uncertain. In this study, we investigated the therapeutic effects of MF on collagen-induced arthritis (CIA).<h4>Methods</h4>CIA was induced in rats by intradermal injection of a mixture of bovine type II collagen and incomplete Freund's adjuvant (IFA) on day 0 and day 7 through the base of the tail. Intraperitoneal injection of MF (100 mg/kg) was given every 3 days, from day 14 for 3 weeks. The effects of MF on arthritis-induced systemic inflammation and synovitis were studied by pathological analysis of the knee joint and serological examination of peripheral blood in CIA raAnnals of translational medicine1565https://www.ebi.ac.uk/biostudies/studies/S-EPMC7791269biostudies-literatureMetformin inhibits inflammation and bone destruction in collagen-induced arthritis in rats.PMC7791269Fan KJZhao FTWu JWang TYXu BXWang QSfalseMetformin inhibits inflammation and bone destruction in collagen-induced arthritis in rats.<h4>Background</h4>Metformin (MF) is a widely used biguanide oral hypoglycemic agent, which has obvious anti-inflammatory and immunomodulatory effects. However, the mechanism of MF on rheumatoid arthritis (RA) remains uncertain. In this study, we investigated the therapeutic effects of MF on collagen-induced arthritis (CIA).<h4>Methods</h4>CIA was induced in rats by intradermal injection of a mixture of bovine type II collagen and incomplete Freund's adjuvant (IFA) on day 0 and day 7 through the base of the tail. Intraperitoneal injection of MF (100 mg/kg) was given every 3 days, from day 14 for 3 weeks. The effects of MF on arthritis-induced systemic inflammation and synovitis were studied by pathological analysis of the knee joint and serological examination of peripheral blood in CIA ra2020-01-01T00:00:00Z2020 Dec2025-04-05T16:07:19.649Z2025-04-05T16:07:19.649ZS-EPMC77912693343776410.21037/atm-20-3042