{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Huang L"],"pubmed_abstract":["<h4>Background</h4>Pancreatic cancer is a fatal disease with a very poor prognosis due to its characteristic insidious symptoms, early metastasis, and chemoresistance. Circular RNAs (circRNAs) are involved in the development of pancreatic cancer.<h4>Aim</h4>Hence, the aim of this study is to elucidate the mechanism of circRNA_000864 in regulating BTG2 expression in pancreatic cancer by binding to miR-361-3p.<h4>Methods</h4>CircRNA_000864, miR-361-3p, and BTG2 expression patterns in the pancreatic cancer tissues were detected by RT-qPCR. Correlation among circRNA_000864, miR-361-3p, and BTG2 was evaluated by RNA-pull down assay, RNA Immunoprecipitation assay, and dual-luciferase reporter gene assay. After ectopic expression and depletion experiments, 5-ethynyl-2'-deoxyuridine assay, Transwe"],"journal":["Frontiers in oncology"],"pagination":["547942"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7793745"],"repository":["biostudies-literature"],"pubmed_title":["CircRNA_000864 Upregulates B-cell Translocation Gene 2 Expression and Represses Migration and Invasion in Pancreatic Cancer Cells by Binding to miR-361-3p."],"pmcid":["PMC7793745"],"pubmed_authors":["Wu Z","Liu J","Su S","Fu G","Li F","Gui L","Huang L","Han J","Yu H","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"CircRNA_000864 Upregulates B-cell Translocation Gene 2 Expression and Represses Migration and Invasion in Pancreatic Cancer Cells by Binding to miR-361-3p.","description":"<h4>Background</h4>Pancreatic cancer is a fatal disease with a very poor prognosis due to its characteristic insidious symptoms, early metastasis, and chemoresistance. Circular RNAs (circRNAs) are involved in the development of pancreatic cancer.<h4>Aim</h4>Hence, the aim of this study is to elucidate the mechanism of circRNA_000864 in regulating BTG2 expression in pancreatic cancer by binding to miR-361-3p.<h4>Methods</h4>CircRNA_000864, miR-361-3p, and BTG2 expression patterns in the pancreatic cancer tissues were detected by RT-qPCR. Correlation among circRNA_000864, miR-361-3p, and BTG2 was evaluated by RNA-pull down assay, RNA Immunoprecipitation assay, and dual-luciferase reporter gene assay. After ectopic expression and depletion experiments, 5-ethynyl-2'-deoxyuridine assay, Transwe","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-07T17:12:22.826Z","creation":"2021-02-20T21:35:49Z"},"accession":"S-EPMC7793745","cross_references":{"pubmed":["33425718"],"doi":["10.3389/fonc.2020.547942"]}}