{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["Nantong University","Jiangsu Postdoctoral Research Foundation"],"pagination":["568440"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7793841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<h4>Background</h4>Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is protein contained in the membrane of the endoplasmic reticulum. In lung adenocarcinoma (LUAD), the molecular function of ERLIN2 and the correlation between ERLIN2 and tumor-infiltrating immune cells have been unclear. The aim of our study was to determine the role of ERLIN2 in LUAD development to provide a better understanding of the molecular pathogenesis of this disease and identify new therapeutic targets for its treatment.<h4>Methods</h4>Immunohistochemistry, Western blotting, and real-time quantitative polymerase chain reaction were used to detect protein and mRNA levels of ERLIN2 in LUAD and adjacent normal tissues. Using the A549, H1299 cell line, ERLIN2-short hairpin RNA was applied to silence ERLI"],"journal":["Frontiers in immunology"],"pubmed_title":["Molecular and Immune Characteristics for Lung Adenocarcinoma Patients With ERLIN2 Overexpression."],"pmcid":["PMC7793841"],"funding_grant_id":["No. 2019Z142","No. 2019JQ001"],"pubmed_authors":["Liu Y","Liu J","Zhang J","Jiang D","Shi J","Xie P","Bian T"],"additional_accession":[]},"is_claimable":false,"name":"Molecular and Immune Characteristics for Lung Adenocarcinoma Patients With ERLIN2 Overexpression.","description":"<h4>Background</h4>Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is protein contained in the membrane of the endoplasmic reticulum. In lung adenocarcinoma (LUAD), the molecular function of ERLIN2 and the correlation between ERLIN2 and tumor-infiltrating immune cells have been unclear. The aim of our study was to determine the role of ERLIN2 in LUAD development to provide a better understanding of the molecular pathogenesis of this disease and identify new therapeutic targets for its treatment.<h4>Methods</h4>Immunohistochemistry, Western blotting, and real-time quantitative polymerase chain reaction were used to detect protein and mRNA levels of ERLIN2 in LUAD and adjacent normal tissues. Using the A549, H1299 cell line, ERLIN2-short hairpin RNA was applied to silence ERLI","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-18T23:29:23.606Z","creation":"2021-02-20T20:45:11Z"},"accession":"S-EPMC7793841","cross_references":{"pubmed":["33424830"],"doi":["10.3389/fimmu.2020.568440"]}}