biostudies-literatureLiu YNantong UniversityJiangsu Postdoctoral Research Foundation568440https://www.ebi.ac.uk/biostudies/studies/S-EPMC7793841biostudies-literatureUnknown11<h4>Background</h4>Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is protein contained in the membrane of the endoplasmic reticulum. In lung adenocarcinoma (LUAD), the molecular function of ERLIN2 and the correlation between ERLIN2 and tumor-infiltrating immune cells have been unclear. The aim of our study was to determine the role of ERLIN2 in LUAD development to provide a better understanding of the molecular pathogenesis of this disease and identify new therapeutic targets for its treatment.<h4>Methods</h4>Immunohistochemistry, Western blotting, and real-time quantitative polymerase chain reaction were used to detect protein and mRNA levels of ERLIN2 in LUAD and adjacent normal tissues. Using the A549, H1299 cell line, ERLIN2-short hairpin RNA was applied to silence ERLIFrontiers in immunologyMolecular and Immune Characteristics for Lung Adenocarcinoma Patients With ERLIN2 Overexpression.PMC7793841No. 2019Z142No. 2019JQ001Liu YLiu JZhang JJiang DShi JXie PBian TfalseMolecular and Immune Characteristics for Lung Adenocarcinoma Patients With ERLIN2 Overexpression.<h4>Background</h4>Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is protein contained in the membrane of the endoplasmic reticulum. In lung adenocarcinoma (LUAD), the molecular function of ERLIN2 and the correlation between ERLIN2 and tumor-infiltrating immune cells have been unclear. The aim of our study was to determine the role of ERLIN2 in LUAD development to provide a better understanding of the molecular pathogenesis of this disease and identify new therapeutic targets for its treatment.<h4>Methods</h4>Immunohistochemistry, Western blotting, and real-time quantitative polymerase chain reaction were used to detect protein and mRNA levels of ERLIN2 in LUAD and adjacent normal tissues. Using the A549, H1299 cell line, ERLIN2-short hairpin RNA was applied to silence ERLI2020-01-01T00:00:00Z20202025-04-18T23:29:23.606Z2021-02-20T20:45:11ZS-EPMC77938413342483010.3389/fimmu.2020.568440