biostudies-literatureUnknown22(1)Thangaraju KRed blood cells (RBCs) release extracellular vesicles (EVs) including both endosome-derived exosomes and plasma-membrane-derived microvesicles (MVs). RBC-derived EVs (RBCEVs) are secreted during erythropoiesis, physiological cellular aging, disease conditions, and in response to environmental stressors. RBCEVs are enriched in various bioactive molecules that facilitate cell to cell communication and can act as markers of disease. RBCEVs contribute towards physiological adaptive responses to hypoxia as well as pathophysiological progression of diabetes and genetic non-malignant hematologic disease. Moreover, a considerable number of studies focus on the role of EVs from stored RBCs and have evaluated post transfusion consequences associated with their exposure. Interestingly, RBCEVs are impInternational journal of molecular sciencesE153https://www.ebi.ac.uk/biostudies/studies/S-EPMC7796437biostudies-literatureExtracellular Vesicles from Red Blood Cells and Their Evolving Roles in Health, Coagulopathy and Therapy.PMC7796437Thangaraju KBuehler PWNeerukonda SNKatneni UfalseExtracellular Vesicles from Red Blood Cells and Their Evolving Roles in Health, Coagulopathy and Therapy.Red blood cells (RBCs) release extracellular vesicles (EVs) including both endosome-derived exosomes and plasma-membrane-derived microvesicles (MVs). RBC-derived EVs (RBCEVs) are secreted during erythropoiesis, physiological cellular aging, disease conditions, and in response to environmental stressors. RBCEVs are enriched in various bioactive molecules that facilitate cell to cell communication and can act as markers of disease. RBCEVs contribute towards physiological adaptive responses to hypoxia as well as pathophysiological progression of diabetes and genetic non-malignant hematologic disease. Moreover, a considerable number of studies focus on the role of EVs from stored RBCs and have evaluated post transfusion consequences associated with their exposure. Interestingly, RBCEVs are imp2020-01-01T00:00:00Z2020 Dec2025-04-26T02:03:18.633Z2021-02-20T20:51:23ZS-EPMC77964373337571810.3390/ijms22010153