{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(12)"],"submitter":["Guinde J"],"pubmed_abstract":["<h4>Background</h4>Appropriate pre-operative staging is a cornerstone in the treatment of non-small cell lung cancer (NSCLC). Central location and size greater than 3 cm are amongst indications for pre-operative invasive mediastinal staging but the quality of the evidence behind this recommendation is low.<h4>Methods</h4>We retrospectively reviewed all cases of cT2-4N0M0 NSCLCL after CT and TEP-CT which underwent surgical resection with lymph node dissection or had a positive invasive pre-operative mediastinal staging in our institution from 2014 to 2018.<h4>Results</h4>Three hundred and ten patients met inclusion criteria, 79 (25.5%) central and 231 (74.5%) peripheral tumors. Central tumor location was associated with a higher prevalence of pN2-3 disease (17.7% <i>vs.</i> 6.1%, P<0.001). "],"journal":["Journal of thoracic disease"],"pagination":["7156-7163"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7797819"],"repository":["biostudies-literature"],"pubmed_title":["Central location and risk of imaging occult mediastinal lymph node involvement in cN0T2-4 non-small cell lung cancer."],"pmcid":["PMC7797819"],"pubmed_authors":["Guinde J","Bourdages-Pageau E","Ugalde PA","Fortin M"],"additional_accession":[]},"is_claimable":false,"name":"Central location and risk of imaging occult mediastinal lymph node involvement in cN0T2-4 non-small cell lung cancer.","description":"<h4>Background</h4>Appropriate pre-operative staging is a cornerstone in the treatment of non-small cell lung cancer (NSCLC). Central location and size greater than 3 cm are amongst indications for pre-operative invasive mediastinal staging but the quality of the evidence behind this recommendation is low.<h4>Methods</h4>We retrospectively reviewed all cases of cT2-4N0M0 NSCLCL after CT and TEP-CT which underwent surgical resection with lymph node dissection or had a positive invasive pre-operative mediastinal staging in our institution from 2014 to 2018.<h4>Results</h4>Three hundred and ten patients met inclusion criteria, 79 (25.5%) central and 231 (74.5%) peripheral tumors. Central tumor location was associated with a higher prevalence of pN2-3 disease (17.7% <i>vs.</i> 6.1%, P<0.001). ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-04T19:53:47.912Z","creation":"2025-04-04T19:53:47.912Z"},"accession":"S-EPMC7797819","cross_references":{"pubmed":["33447404"],"doi":["10.21037/jtd-20-1565"]}}