biostudies-literatureUnknown12(12)Guinde J<h4>Background</h4>Appropriate pre-operative staging is a cornerstone in the treatment of non-small cell lung cancer (NSCLC). Central location and size greater than 3 cm are amongst indications for pre-operative invasive mediastinal staging but the quality of the evidence behind this recommendation is low.<h4>Methods</h4>We retrospectively reviewed all cases of cT2-4N0M0 NSCLCL after CT and TEP-CT which underwent surgical resection with lymph node dissection or had a positive invasive pre-operative mediastinal staging in our institution from 2014 to 2018.<h4>Results</h4>Three hundred and ten patients met inclusion criteria, 79 (25.5%) central and 231 (74.5%) peripheral tumors. Central tumor location was associated with a higher prevalence of pN2-3 disease (17.7% <i>vs.</i> 6.1%, P<0.001). Journal of thoracic disease7156-7163https://www.ebi.ac.uk/biostudies/studies/S-EPMC7797819biostudies-literatureCentral location and risk of imaging occult mediastinal lymph node involvement in cN0T2-4 non-small cell lung cancer.PMC7797819Guinde JBourdages-Pageau EUgalde PAFortin MfalseCentral location and risk of imaging occult mediastinal lymph node involvement in cN0T2-4 non-small cell lung cancer.<h4>Background</h4>Appropriate pre-operative staging is a cornerstone in the treatment of non-small cell lung cancer (NSCLC). Central location and size greater than 3 cm are amongst indications for pre-operative invasive mediastinal staging but the quality of the evidence behind this recommendation is low.<h4>Methods</h4>We retrospectively reviewed all cases of cT2-4N0M0 NSCLCL after CT and TEP-CT which underwent surgical resection with lymph node dissection or had a positive invasive pre-operative mediastinal staging in our institution from 2014 to 2018.<h4>Results</h4>Three hundred and ten patients met inclusion criteria, 79 (25.5%) central and 231 (74.5%) peripheral tumors. Central tumor location was associated with a higher prevalence of pN2-3 disease (17.7% <i>vs.</i> 6.1%, P<0.001). 2020-01-01T00:00:00Z2020 Dec2025-04-04T19:53:47.912Z2025-04-04T19:53:47.912ZS-EPMC77978193344740410.21037/jtd-20-1565