{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Agrawal I"],"funding":["Ministry of Electronics and Information technology","Department of Biotechnology, Ministry of Science and Technology, India"],"pubmed_abstract":["Dopamine (DA) plays many roles in the brain, especially in movement, motivation, and reinforcement of behavior; however, its role in regulating innate immunity is not clear. Here, we show that DA can induce DNA-based extracellular traps in primary, adult, human microglia and BV2 microglia cell line. These DNA-based extracellular traps are formed independent of reactive oxygen species, actin polymerization, and cell death. These traps are functional and capture fluorescein (FITC)-tagged <i>Escherichia coli</i> even when reactive oxygen species production or actin polymerization is inhibited. We show that microglial extracellular traps are present in <i>Glioblastoma multiforme</i>. This is crucial because <i>Glioblastoma multiforme</i> cells are known to secrete DA. Our findings demonstrate "],"journal":["iScience"],"pagination":["101968"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7797945"],"repository":["biostudies-literature"],"pubmed_title":["Dopamine induces functional extracellular traps in microglia."],"pmcid":["PMC7797945"],"pubmed_authors":["Ghatak S","Sharma N","Gupta T","Arvind S","Chakraborty D","Jha D","Jha S","Agrawal I","Saxena S","Epari S","Chakraborty DB"],"additional_accession":[]},"is_claimable":false,"name":"Dopamine induces functional extracellular traps in microglia.","description":"Dopamine (DA) plays many roles in the brain, especially in movement, motivation, and reinforcement of behavior; however, its role in regulating innate immunity is not clear. Here, we show that DA can induce DNA-based extracellular traps in primary, adult, human microglia and BV2 microglia cell line. These DNA-based extracellular traps are formed independent of reactive oxygen species, actin polymerization, and cell death. These traps are functional and capture fluorescein (FITC)-tagged <i>Escherichia coli</i> even when reactive oxygen species production or actin polymerization is inhibited. We show that microglial extracellular traps are present in <i>Glioblastoma multiforme</i>. This is crucial because <i>Glioblastoma multiforme</i> cells are known to secrete DA. Our findings demonstrate ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-05-04T19:14:05.478Z","creation":"2021-02-21T00:03:08Z"},"accession":"S-EPMC7797945","cross_references":{"pubmed":["33458617"],"doi":["10.1016/j.isci.2020.101968"]}}