{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng J"],"funding":["NIAID NIH HHS","National Institutes of Health"],"pagination":["785-795"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7799009"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["223(5)"],"pubmed_abstract":["Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients and experimentally infected animals indicate a critical role for augmented expression of proinflammatory chemokines and cytokines in severe disease. Here, we demonstrate that SARS-CoV-2 infection of human monocyte-derived macrophages (MDMs) and monocyte-derived dendritic cells was abortive, but induced the production of multiple antiviral and proinflammatory cytokines (interferon-α, interferon-β, tumor necrosis factor, and interleukins 1β, 6, and 10) and a chemokine (CXCL10). Despite the lack of efficient replication in MDMs, SARS-CoV-2 induced profound interferon-mediated cell death of host cells. Macrophage activation and death were not enhanced by exposure to low levels of convalescent plasma, suggesting that antibody-dependent enhancement of infection does not contribute to cell death. Together, these results indicate that infection of macrophages and dendritic cells potentially plays a major role in coronavirus disease 2019 pathogenesis, even in the absence of productive infection."],"journal":["The Journal of infectious diseases"],"pubmed_title":["Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells."],"pmcid":["PMC7799009"],"funding_grant_id":["R01 AI129269","RO1 AI129269","PO1 AI060699","P01 AI060699"],"pubmed_authors":["Zheng J","Meyerholz DK","Allamargot C","Perlman S","Wang Y","Li K"],"additional_accession":[]},"is_claimable":false,"name":"Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells.","description":"Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients and experimentally infected animals indicate a critical role for augmented expression of proinflammatory chemokines and cytokines in severe disease. Here, we demonstrate that SARS-CoV-2 infection of human monocyte-derived macrophages (MDMs) and monocyte-derived dendritic cells was abortive, but induced the production of multiple antiviral and proinflammatory cytokines (interferon-α, interferon-β, tumor necrosis factor, and interleukins 1β, 6, and 10) and a chemokine (CXCL10). Despite the lack of efficient replication in MDMs, SARS-CoV-2 induced profound interferon-mediated cell death of host cells. Macrophage activation and death were not enhanced by exposure to low levels of convalescent plasma, suggesting that antibody-dependent enhancement of infection does not contribute to cell death. Together, these results indicate that infection of macrophages and dendritic cells potentially plays a major role in coronavirus disease 2019 pathogenesis, even in the absence of productive infection.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-04-07T21:52:23.309Z","creation":"2021-03-14T08:18:12Z"},"accession":"S-EPMC7799009","cross_references":{"pubmed":["33277988"],"doi":["10.1093/infdis/jiaa753"]}}