{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mody A"],"funding":["National Center for Advancing Translational Sciences","National Institute of Allergy and Infectious Diseases","NCATS NIH HHS","NIAID NIH HHS"],"pagination":["539-552"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7799307"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["190(4)"],"pubmed_abstract":["There are limited data on longitudinal outcomes for coronavirus disease 2019 (COVID-19) hospitalizations that account for transitions between clinical states over time. Using electronic health record data from a hospital network in the St. Louis, Missouri, region, we performed multistate analyses to examine longitudinal transitions and outcomes among hospitalized adults with laboratory-confirmed COVID-19 with respect to 15 mutually exclusive clinical states. Between March 15 and July 25, 2020, a total of 1,577 patients in the network were hospitalized with COVID-19 (49.9% male; median age, 63 years (interquartile range, 50-75); 58.8% Black). Overall, 34.1% (95% confidence interval (CI): 26.4, 41.8) had an intensive care unit admission and 12.3% (95% CI: 8.5, 16.1) received invasive mechanical ventilation (IMV). The risk of decompensation peaked immediately after admission; discharges peaked around days 3-5, and deaths plateaued between days 7 and 16. At 28 days, 12.6% (95% CI: 9.6, 15.6) of patients had died (4.2% (95% CI: 3.2, 5.2) had received IMV) and 80.8% (95% CI: 75.4, 86.1) had been discharged. Among those receiving IMV, 35.1% (95% CI: 28.2, 42.0) remained intubated after 14 days; after 28 days, 37.6% (95% CI: 30.4, 44.7) had died and only 37.7% (95% CI: 30.6, 44.7) had been discharged. Multistate methods offer granular characterizations of the clinical course of COVID-19 and provide essential information for guiding both clinical decision-making and public health planning."],"journal":["American journal of epidemiology"],"pubmed_title":["The Clinical Course of Coronavirus Disease 2019 in a US Hospital System: A Multistate Analysis."],"pmcid":["PMC7799307"],"funding_grant_id":["TR002346 to AM","K24 AI134413","KL2 TR002346","K24 AI134413 to EHG"],"pubmed_authors":["Namwase AS","Sinha P","Woeltje K","Yu S","Powderly WG","Mody A","Lyons PG","Michelson A","Vazquez Guillamet C","Geng EH"],"additional_accession":[]},"is_claimable":false,"name":"The Clinical Course of Coronavirus Disease 2019 in a US Hospital System: A Multistate Analysis.","description":"There are limited data on longitudinal outcomes for coronavirus disease 2019 (COVID-19) hospitalizations that account for transitions between clinical states over time. Using electronic health record data from a hospital network in the St. Louis, Missouri, region, we performed multistate analyses to examine longitudinal transitions and outcomes among hospitalized adults with laboratory-confirmed COVID-19 with respect to 15 mutually exclusive clinical states. Between March 15 and July 25, 2020, a total of 1,577 patients in the network were hospitalized with COVID-19 (49.9% male; median age, 63 years (interquartile range, 50-75); 58.8% Black). Overall, 34.1% (95% confidence interval (CI): 26.4, 41.8) had an intensive care unit admission and 12.3% (95% CI: 8.5, 16.1) received invasive mechanical ventilation (IMV). The risk of decompensation peaked immediately after admission; discharges peaked around days 3-5, and deaths plateaued between days 7 and 16. At 28 days, 12.6% (95% CI: 9.6, 15.6) of patients had died (4.2% (95% CI: 3.2, 5.2) had received IMV) and 80.8% (95% CI: 75.4, 86.1) had been discharged. Among those receiving IMV, 35.1% (95% CI: 28.2, 42.0) remained intubated after 14 days; after 28 days, 37.6% (95% CI: 30.4, 44.7) had died and only 37.7% (95% CI: 30.6, 44.7) had been discharged. Multistate methods offer granular characterizations of the clinical course of COVID-19 and provide essential information for guiding both clinical decision-making and public health planning.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2024-10-16T05:39:28.221Z","creation":"2022-02-11T13:10:56.835Z"},"accession":"S-EPMC7799307","cross_references":{"pubmed":["33351077"],"doi":["10.1093/aje/kwaa286"]}}