{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Cheng S"],"funding":["Peking University First Hospital, Sun Yat-sen Memorial Hospital, Peking University Third Hospital and Fujian Provincial Hospital"],"pubmed_abstract":["Locally advanced upper urinary tract urothelial carcinoma (UTUC) exhibits high recurrence and metastasis rates even after radical nephroureterectomy. Adjuvant immunotherapy can be a reasonable option, and a simple, low-cost, and effective biomarker is further needed. Stromal tumor-infiltrating lymphocytes (sTILs) has been demonstrated as a prognostic and predictive biomarker in various tumor types, but not yet in locally advanced UTUC. In this multicenter, real-world and retrospective study, we tried to investigate the prognostic role of sTIL and its correlation with the PD-L1/PD-1/CD8 axis by reviewing the clinicopathologic variables of 398 locally advanced UTUC patients at four high-volume Chinese medical centers. sTIL density was evaluated with standardized methodology on H&E sections, "],"journal":["Oncoimmunology"],"pagination":["1861737"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7801121"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic role of stromal tumor-infiltrating lymphocytes in locally advanced upper tract urothelial carcinoma: A retrospective multicenter study (TSU-02 study)."],"pmcid":["PMC7801121"],"pubmed_authors":["Zhou L","Lin R","Ma L","Wang B","Chen J","Lin T","Huang J","Zhang H","Zhong W","Cheng S","Li X","Ye L","Xia K","Liu Z","Liu C","Hong P"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic role of stromal tumor-infiltrating lymphocytes in locally advanced upper tract urothelial carcinoma: A retrospective multicenter study (TSU-02 study).","description":"Locally advanced upper urinary tract urothelial carcinoma (UTUC) exhibits high recurrence and metastasis rates even after radical nephroureterectomy. Adjuvant immunotherapy can be a reasonable option, and a simple, low-cost, and effective biomarker is further needed. Stromal tumor-infiltrating lymphocytes (sTILs) has been demonstrated as a prognostic and predictive biomarker in various tumor types, but not yet in locally advanced UTUC. In this multicenter, real-world and retrospective study, we tried to investigate the prognostic role of sTIL and its correlation with the PD-L1/PD-1/CD8 axis by reviewing the clinicopathologic variables of 398 locally advanced UTUC patients at four high-volume Chinese medical centers. sTIL density was evaluated with standardized methodology on H&E sections, ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-05-31T23:35:09.659Z","creation":"2025-05-31T23:35:09.659Z"},"accession":"S-EPMC7801121","cross_references":{"pubmed":["33489471"],"doi":["10.1080/2162402X.2020.1861737"]}}