{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Kushawaha B"],"pubmed_abstract":["Earlier we have reported mercury-induced alterations in functional dynamics of buck spermatozoa through free radicals-mediated oxidative stress and spontaneous acrosome reaction. Based on our earlier findings, we aimed to investigate the effect of mercury exposure on motility, kinematic patterns, DNA damage, apoptosis and ultra-structural alterations in goat spermatozoa following in vitro exposure to different concentrations (0.031-1.25 µg/ml) of mercuric chloride for 15 min and 3 h. Following exposure of sperm cells to 0.031 µg/ml of mercuric chloride for 3 h, livability and motility of sperms was significantly reduced along with altered kinematic patterns, significant increase in per cent necrotic sperm cells and number of cells showing DNA damage; and this effect was dose- and time-depe"],"journal":["Scientific reports"],"pagination":["646"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7804962"],"repository":["biostudies-literature"],"pubmed_title":["Collapsed mitochondrial cristae in goat spermatozoa due to mercury result in lethality and compromised motility along with altered kinematic patterns."],"pmcid":["PMC7804962"],"pubmed_authors":["Swain DK","Anand M","Yadav RS","Kumari P","Kushawaha B","Yadav S","Yadav B","Kumar A","Singh D","Garg SK"],"additional_accession":[]},"is_claimable":false,"name":"Collapsed mitochondrial cristae in goat spermatozoa due to mercury result in lethality and compromised motility along with altered kinematic patterns.","description":"Earlier we have reported mercury-induced alterations in functional dynamics of buck spermatozoa through free radicals-mediated oxidative stress and spontaneous acrosome reaction. Based on our earlier findings, we aimed to investigate the effect of mercury exposure on motility, kinematic patterns, DNA damage, apoptosis and ultra-structural alterations in goat spermatozoa following in vitro exposure to different concentrations (0.031-1.25 µg/ml) of mercuric chloride for 15 min and 3 h. Following exposure of sperm cells to 0.031 µg/ml of mercuric chloride for 3 h, livability and motility of sperms was significantly reduced along with altered kinematic patterns, significant increase in per cent necrotic sperm cells and number of cells showing DNA damage; and this effect was dose- and time-depe","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-04-15T09:07:37.716Z","creation":"2021-02-21T00:36:56Z"},"accession":"S-EPMC7804962","cross_references":{"pubmed":["33436823"],"doi":["10.1038/s41598-020-80235-y"]}}