{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Neelam"],"funding":["Department of Science and Technology, Ministry of Science and Technology"],"pagination":["70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7806689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Novel derivatives were synthesized using natural scaffold, like phenylpropanoids C<sub>6</sub>-C<sub>3</sub> backbone to reduce unfavorable browning of food due to tyrosinase and oxidative spoilage. Most of the compounds displayed mushroom tyrosinase inhibition better than kojic acid. Compound CE48 exhibited better anti-tyrosinase (IC<sub>50</sub>-29.64 μM) and antioxidant (EC<sub>50</sub>-12.67 μM) activity than the reference compounds, kojic acid (IC<sub>50</sub>-50.30 μM) and ascorbic acid (EC<sub>50</sub>-14.55 μM), respectively. Compounds SAM30, SE78, 11F, and CE48 showed better anti-<i>B. subtilis</i>, anti-<i>S. aureus</i>, and anti-<i>A. niger</i> activity, respectively, compared to their parents. Molecular docking studies between inhibitors and mushroom tyrosinase corroborated the"],"journal":["3 Biotech"],"pubmed_title":["Bioevaluation and molecular docking analysis of novel phenylpropanoid derivatives as potent food preservative and anti-microbials."],"pmcid":["PMC7806689"],"funding_grant_id":["1196 SR/FST/LS-I/2017/4"],"pubmed_authors":["Neelam","Shankar A","Lather A","Khatkar A","Ahlawat S","Sharma KK"],"additional_accession":[]},"is_claimable":false,"name":"Bioevaluation and molecular docking analysis of novel phenylpropanoid derivatives as potent food preservative and anti-microbials.","description":"Novel derivatives were synthesized using natural scaffold, like phenylpropanoids C<sub>6</sub>-C<sub>3</sub> backbone to reduce unfavorable browning of food due to tyrosinase and oxidative spoilage. Most of the compounds displayed mushroom tyrosinase inhibition better than kojic acid. Compound CE48 exhibited better anti-tyrosinase (IC<sub>50</sub>-29.64 μM) and antioxidant (EC<sub>50</sub>-12.67 μM) activity than the reference compounds, kojic acid (IC<sub>50</sub>-50.30 μM) and ascorbic acid (EC<sub>50</sub>-14.55 μM), respectively. Compounds SAM30, SE78, 11F, and CE48 showed better anti-<i>B. subtilis</i>, anti-<i>S. aureus</i>, and anti-<i>A. niger</i> activity, respectively, compared to their parents. Molecular docking studies between inhibitors and mushroom tyrosinase corroborated the","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-04-14T17:54:43.29Z","creation":"2022-02-11T15:46:32.183Z"},"accession":"S-EPMC7806689","cross_references":{"pubmed":["33489687"],"doi":["10.1007/s13205-020-02636-0"]}}