biostudies-literatureNeelamDepartment of Science and Technology, Ministry of Science and Technology70https://www.ebi.ac.uk/biostudies/studies/S-EPMC7806689biostudies-literatureUnknown11(2)Novel derivatives were synthesized using natural scaffold, like phenylpropanoids C<sub>6</sub>-C<sub>3</sub> backbone to reduce unfavorable browning of food due to tyrosinase and oxidative spoilage. Most of the compounds displayed mushroom tyrosinase inhibition better than kojic acid. Compound CE48 exhibited better anti-tyrosinase (IC<sub>50</sub>-29.64 μM) and antioxidant (EC<sub>50</sub>-12.67 μM) activity than the reference compounds, kojic acid (IC<sub>50</sub>-50.30 μM) and ascorbic acid (EC<sub>50</sub>-14.55 μM), respectively. Compounds SAM30, SE78, 11F, and CE48 showed better anti-<i>B. subtilis</i>, anti-<i>S. aureus</i>, and anti-<i>A. niger</i> activity, respectively, compared to their parents. Molecular docking studies between inhibitors and mushroom tyrosinase corroborated the3 BiotechBioevaluation and molecular docking analysis of novel phenylpropanoid derivatives as potent food preservative and anti-microbials.PMC78066891196 SR/FST/LS-I/2017/4NeelamShankar ALather AKhatkar AAhlawat SSharma KKfalseBioevaluation and molecular docking analysis of novel phenylpropanoid derivatives as potent food preservative and anti-microbials.Novel derivatives were synthesized using natural scaffold, like phenylpropanoids C<sub>6</sub>-C<sub>3</sub> backbone to reduce unfavorable browning of food due to tyrosinase and oxidative spoilage. Most of the compounds displayed mushroom tyrosinase inhibition better than kojic acid. Compound CE48 exhibited better anti-tyrosinase (IC<sub>50</sub>-29.64 μM) and antioxidant (EC<sub>50</sub>-12.67 μM) activity than the reference compounds, kojic acid (IC<sub>50</sub>-50.30 μM) and ascorbic acid (EC<sub>50</sub>-14.55 μM), respectively. Compounds SAM30, SE78, 11F, and CE48 showed better anti-<i>B. subtilis</i>, anti-<i>S. aureus</i>, and anti-<i>A. niger</i> activity, respectively, compared to their parents. Molecular docking studies between inhibitors and mushroom tyrosinase corroborated the2021-01-01T00:00:00Z2021 Feb2026-04-14T17:54:43.29Z2022-02-11T15:46:32.183ZS-EPMC78066893348968710.1007/s13205-020-02636-0