{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh A"],"funding":["Bundesministerium f?r Bildung und Forschung","Department of Biotechnology , Ministry of Science and Technology","Einstein Stiftung Berlin","Defence Research and Development Organisation"],"pagination":["103-112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7807463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["Pyrimidine-based cationic amphiphiles (PCAms), i.e., di-trifluoroacetic acid salts of <i>N</i>1-[1'-(1″,3″-diglycinatoxy-propane-2″-yl)-1',2',3'-triazole-4'-yl]methyl-<i>N</i>3-alkylpyrimidines have been synthesized utilizing naturally occurring biocompatible precursors, like glycerol, glycine, and uracil/ thymine in good yields. Synthesized PCAms consist of a hydrophilic head group comprising TFA salt of glyceryl 1,3-diglycinate and hydrophobic tail comprising of C-7 and C-12 <i>N</i>3-alkylated uracil or thymine conjugated via a 4-methylene-1,2,3-triazolyl linker. The physicochemical properties of all PCAms, such as critical aggregation concentration, hydrodynamic diameter, shape, and zeta potential (surface charge) were analyzed. These PCAms were also evaluated for their anti-proliferat"],"journal":["ACS omega"],"pubmed_title":["Synthesis, Self-Assembly, and Biological Activities of Pyrimidine-Based Cationic Amphiphiles."],"pmcid":["PMC7807463"],"funding_grant_id":["13N12561"],"pubmed_authors":["Bimal D","Prasad AK","Calderon M","Singh A","Malhotra S","Wedepohl S","Bouchet LM"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, Self-Assembly, and Biological Activities of Pyrimidine-Based Cationic Amphiphiles.","description":"Pyrimidine-based cationic amphiphiles (PCAms), i.e., di-trifluoroacetic acid salts of <i>N</i>1-[1'-(1″,3″-diglycinatoxy-propane-2″-yl)-1',2',3'-triazole-4'-yl]methyl-<i>N</i>3-alkylpyrimidines have been synthesized utilizing naturally occurring biocompatible precursors, like glycerol, glycine, and uracil/ thymine in good yields. Synthesized PCAms consist of a hydrophilic head group comprising TFA salt of glyceryl 1,3-diglycinate and hydrophobic tail comprising of C-7 and C-12 <i>N</i>3-alkylated uracil or thymine conjugated via a 4-methylene-1,2,3-triazolyl linker. The physicochemical properties of all PCAms, such as critical aggregation concentration, hydrodynamic diameter, shape, and zeta potential (surface charge) were analyzed. These PCAms were also evaluated for their anti-proliferat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-26T02:08:03.612Z","creation":"2025-04-06T10:19:59.836Z"},"accession":"S-EPMC7807463","cross_references":{"pubmed":["33458463"],"doi":["10.1021/acsomega.0c03623"]}}