biostudies-literaturede Araujo NDCoordenação de Aperfeiçoamento de Pessoal de Nível Superior6633824https://www.ebi.ac.uk/biostudies/studies/S-EPMC7808823biostudies-literatureUnknown2021Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell populations, which include gamma-delta T cells (<i>γδ</i>), natural killer T cells (NKT), and mucosal-associated invariant T cells (MAIT). Collectively, these T cell populations can recognize lipid antigens, specially modified peptides and small molecule metabolites, in addition to having several other advantages, which can provide more effective applications in cancer immunotherapy. In recent yeJournal of immunology researchTranslating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity.PMC7808823Pró-Estado Program-#002/2008PAMEQ Program-#004/2019PAPAC Program-#005/2019Malheiro Ade Araujo NDGama FMde Souza Barros MXabregas LARibeiro TLPTarrago AMAlves FSCosta AGfalseTranslating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity.Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell populations, which include gamma-delta T cells (<i>γδ</i>), natural killer T cells (NKT), and mucosal-associated invariant T cells (MAIT). Collectively, these T cell populations can recognize lipid antigens, specially modified peptides and small molecule metabolites, in addition to having several other advantages, which can provide more effective applications in cancer immunotherapy. In recent ye2021-01-01T00:00:00Z20212025-04-22T18:40:39.608Z2021-02-21T04:12:41ZS-EPMC78088233350605510.1155/2021/6633824