{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(24)"],"submitter":["Wu X"],"pubmed_abstract":["<h4>Background</h4>Skin precursor-derived Schwann cells (SKP-SCs) have been shown to benefit the recovery of spinal cord injury (SCI) and peripheral nerve injury (PNI) with motor dysfunction. However, the effect of extracellular vesicles (EVs) from SKP-SCs responsible for neuroregeneration remains unknown.<h4>Methods</h4>Based on the obtainment and identification of rat SKP-SCs and their derived EVs, the primary rat injury model of motoneurons resulting from axotomy <i>in vitro</i> or nerve crush <i>in vivo</i>, as well as the secondary rat ischemic hypoxic injury model of motoneuron exposure to oxygen-glucose-deprivation (OGD) <i>in vitro</i>, were treated with EVs from skin precursor-derived Schwann cells (SKP-SC-EVs), respectively. Then, the axonal outgrowth and regrowth was observed an"],"journal":["Annals of translational medicine"],"pagination":["1640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7812244"],"repository":["biostudies-literature"],"pubmed_title":["Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway."],"pmcid":["PMC7812244"],"pubmed_authors":["Shen M","Ding F","Cong M","He Q","Shi H","Wu X","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.","description":"<h4>Background</h4>Skin precursor-derived Schwann cells (SKP-SCs) have been shown to benefit the recovery of spinal cord injury (SCI) and peripheral nerve injury (PNI) with motor dysfunction. However, the effect of extracellular vesicles (EVs) from SKP-SCs responsible for neuroregeneration remains unknown.<h4>Methods</h4>Based on the obtainment and identification of rat SKP-SCs and their derived EVs, the primary rat injury model of motoneurons resulting from axotomy <i>in vitro</i> or nerve crush <i>in vivo</i>, as well as the secondary rat ischemic hypoxic injury model of motoneuron exposure to oxygen-glucose-deprivation (OGD) <i>in vitro</i>, were treated with EVs from skin precursor-derived Schwann cells (SKP-SC-EVs), respectively. Then, the axonal outgrowth and regrowth was observed an","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-04T19:24:07.587Z","creation":"2025-02-19T01:39:57.782Z"},"accession":"S-EPMC7812244","cross_references":{"pubmed":["33490152"],"doi":["10.21037/atm-20-5965"]}}