biostudies-literatureUnknown8(24)Wu X<h4>Background</h4>Skin precursor-derived Schwann cells (SKP-SCs) have been shown to benefit the recovery of spinal cord injury (SCI) and peripheral nerve injury (PNI) with motor dysfunction. However, the effect of extracellular vesicles (EVs) from SKP-SCs responsible for neuroregeneration remains unknown.<h4>Methods</h4>Based on the obtainment and identification of rat SKP-SCs and their derived EVs, the primary rat injury model of motoneurons resulting from axotomy <i>in vitro</i> or nerve crush <i>in vivo</i>, as well as the secondary rat ischemic hypoxic injury model of motoneuron exposure to oxygen-glucose-deprivation (OGD) <i>in vitro</i>, were treated with EVs from skin precursor-derived Schwann cells (SKP-SC-EVs), respectively. Then, the axonal outgrowth and regrowth was observed anAnnals of translational medicine1640https://www.ebi.ac.uk/biostudies/studies/S-EPMC7812244biostudies-literatureExtracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.PMC7812244Shen MDing FCong MHe QShi HWu XWang LfalseExtracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.<h4>Background</h4>Skin precursor-derived Schwann cells (SKP-SCs) have been shown to benefit the recovery of spinal cord injury (SCI) and peripheral nerve injury (PNI) with motor dysfunction. However, the effect of extracellular vesicles (EVs) from SKP-SCs responsible for neuroregeneration remains unknown.<h4>Methods</h4>Based on the obtainment and identification of rat SKP-SCs and their derived EVs, the primary rat injury model of motoneurons resulting from axotomy <i>in vitro</i> or nerve crush <i>in vivo</i>, as well as the secondary rat ischemic hypoxic injury model of motoneuron exposure to oxygen-glucose-deprivation (OGD) <i>in vitro</i>, were treated with EVs from skin precursor-derived Schwann cells (SKP-SC-EVs), respectively. Then, the axonal outgrowth and regrowth was observed an2020-01-01T00:00:00Z2020 Dec2025-04-04T19:24:07.587Z2025-02-19T01:39:57.782ZS-EPMC78122443349015210.21037/atm-20-5965