{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gobert AP"],"funding":["BLRD VA","NIDDK NIH HHS","NIAID NIH HHS","Crohn's & Colitis Foundation","U.S. Department of Defense","NCI NIH HHS","National Institutes of Health","U.S. Department of Veterans Affairs","NIH HHS","CSRD VA"],"pagination":["108510"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7812972"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(11)"],"pubmed_abstract":["Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinated EIF5A (EIF5A<sup>Hyp</sup>) transports specific mRNAs to ribosomes for translation. We show that DHPS is induced in macrophages by two gastrointestinal pathogens, Helicobacter pylori and Citrobacter rodentium, resulting in enhanced hypusination of EIF5A. EIF5A<sup>Hyp</sup> was also increased in gastric macrophages from patients with H. pylori gastritis. Furthermore, we identify the bacteria-induced immune effectors regulated by hypusination. This set of proteins includes essential constituent"],"journal":["Cell reports"],"pubmed_title":["Hypusination Orchestrates the Antimicrobial Response of Macrophages."],"pmcid":["PMC7812972"],"funding_grant_id":["P01 CA028842","R21 AI142042","P01 CA116087","P30 DK058404","T32 AI138932","R01 DK128200","703003","I01 BX001453","P30 CA068485","R01 DK060581","I01 CX002171","R01 CA190612","S10 OD023514","R01 DK124906"],"pubmed_authors":["Mirmira RG","Latour YL","Barry DP","Calcutt MW","Delagado AG","Allaman MM","Asim M","Gobert AP","Rose KL","Sierra JC","Wilson KT","Finley JL","Verriere TG","Schey KL","Piazuelo MB","Smith TM"],"additional_accession":[]},"is_claimable":false,"name":"Hypusination Orchestrates the Antimicrobial Response of Macrophages.","description":"Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinated EIF5A (EIF5A<sup>Hyp</sup>) transports specific mRNAs to ribosomes for translation. We show that DHPS is induced in macrophages by two gastrointestinal pathogens, Helicobacter pylori and Citrobacter rodentium, resulting in enhanced hypusination of EIF5A. EIF5A<sup>Hyp</sup> was also increased in gastric macrophages from patients with H. pylori gastritis. Furthermore, we identify the bacteria-induced immune effectors regulated by hypusination. This set of proteins includes essential constituent","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-05-04T03:48:57.863Z","creation":"2024-11-20T09:22:58.05Z"},"accession":"S-EPMC7812972","cross_references":{"pubmed":["33326776"],"doi":["10.1016/j.celrep.2020.108510"]}}