{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo CG"],"funding":["Crohn's & Colitis Foundation of America","NIDDK NIH HHS","NCI NIH HHS"],"pagination":["428-435"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7821085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(3)"],"pubmed_abstract":["<h4>Importance</h4>Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults.<h4>Objective</h4>To examine the association between aspirin use and the risk of incident CRC among older adults.<h4>Design, setting, and participants</h4>A pooled analysis was conducted of 2 large US cohort studies, the Nurses' Health Study (June 1, 1980-June 30, 2014) and Health Professionals Follow-up Study (January 1, 1986-January 31, 2014). A total of 94 540 participants aged 70 years or older were included and followed up to June 30, 2014, for women or January 31, 2014, for men. Participants with a diagnosis of any cancer, except nonmelanoma sk"],"journal":["JAMA oncology"],"pubmed_title":["Aspirin Use and Risk of Colorectal Cancer Among Older Adults."],"pmcid":["PMC7821085"],"funding_grant_id":["K01 DK120742","K07 CA218377","R35 CA197735","R01 CA137178","563526","P01 CA087969","690389","R01 CA151993","R35 CA253185","P01 CA055075"],"pubmed_authors":["Ng K","Giovannucci EL","Chan AT","Joshi AD","Guo CG","Drew DA","Leung WK","Ma W","Ogino S","Song M","Cao Y","Meyerhardt JA","Nguyen LH"],"additional_accession":[]},"is_claimable":false,"name":"Aspirin Use and Risk of Colorectal Cancer Among Older Adults.","description":"<h4>Importance</h4>Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults.<h4>Objective</h4>To examine the association between aspirin use and the risk of incident CRC among older adults.<h4>Design, setting, and participants</h4>A pooled analysis was conducted of 2 large US cohort studies, the Nurses' Health Study (June 1, 1980-June 30, 2014) and Health Professionals Follow-up Study (January 1, 1986-January 31, 2014). A total of 94 540 participants aged 70 years or older were included and followed up to June 30, 2014, for women or January 31, 2014, for men. Participants with a diagnosis of any cancer, except nonmelanoma sk","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-18T15:11:02.216Z","creation":"2025-04-07T01:43:42.604Z"},"accession":"S-EPMC7821085","cross_references":{"pubmed":["33475710"],"doi":["10.1001/jamaoncol.2020.7338"]}}