biostudies-literatureGuo CGCrohn's & Colitis Foundation of AmericaNIDDK NIH HHSNCI NIH HHS428-435https://www.ebi.ac.uk/biostudies/studies/S-EPMC7821085biostudies-literatureUnknown7(3)<h4>Importance</h4>Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults.<h4>Objective</h4>To examine the association between aspirin use and the risk of incident CRC among older adults.<h4>Design, setting, and participants</h4>A pooled analysis was conducted of 2 large US cohort studies, the Nurses' Health Study (June 1, 1980-June 30, 2014) and Health Professionals Follow-up Study (January 1, 1986-January 31, 2014). A total of 94 540 participants aged 70 years or older were included and followed up to June 30, 2014, for women or January 31, 2014, for men. Participants with a diagnosis of any cancer, except nonmelanoma skJAMA oncologyAspirin Use and Risk of Colorectal Cancer Among Older Adults.PMC7821085K01 DK120742K07 CA218377R35 CA197735R01 CA137178563526P01 CA087969690389R01 CA151993R35 CA253185P01 CA055075Ng KGiovannucci ELChan ATJoshi ADGuo CGDrew DALeung WKMa WOgino SSong MCao YMeyerhardt JANguyen LHfalseAspirin Use and Risk of Colorectal Cancer Among Older Adults.<h4>Importance</h4>Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults.<h4>Objective</h4>To examine the association between aspirin use and the risk of incident CRC among older adults.<h4>Design, setting, and participants</h4>A pooled analysis was conducted of 2 large US cohort studies, the Nurses' Health Study (June 1, 1980-June 30, 2014) and Health Professionals Follow-up Study (January 1, 1986-January 31, 2014). A total of 94 540 participants aged 70 years or older were included and followed up to June 30, 2014, for women or January 31, 2014, for men. Participants with a diagnosis of any cancer, except nonmelanoma sk2021-01-01T00:00:00Z2021 Mar2025-04-18T15:11:02.216Z2025-04-07T01:43:42.604ZS-EPMC78210853347571010.1001/jamaoncol.2020.7338