biostudies-literatureUnknown40Weng YNational Key Research and Development Program of ChinaPeriodontitis is the sixth most prevalent diseases around the globe, which is closely related to many systemic diseases and affects general health. As the leading cause of tooth loss, periodontitis is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which might be closely related to the activated intracellular reactive oxygen species (ROS) in osteoclasts. Here, we demonstrated triggering receptor expressed on myeloid cells 2 (Trem2) as a key regulator of osteoclastogenesis with the regulation of intracellular ROS signals in periodontitis. In the present study, the expression of Trem2 was significantly upregulated in human alveolar bones diagnosed with chronic periodontitis, as assessed by RNA-seq. In the mice model of periodontitis, the alveolar boneRedox biology101849https://www.ebi.ac.uk/biostudies/studies/S-EPMC7823053biostudies-literatureTrem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment.PMC7823053Feng YWeng YXu SWang HLi LWang ZfalseTrem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment.Periodontitis is the sixth most prevalent diseases around the globe, which is closely related to many systemic diseases and affects general health. As the leading cause of tooth loss, periodontitis is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which might be closely related to the activated intracellular reactive oxygen species (ROS) in osteoclasts. Here, we demonstrated triggering receptor expressed on myeloid cells 2 (Trem2) as a key regulator of osteoclastogenesis with the regulation of intracellular ROS signals in periodontitis. In the present study, the expression of Trem2 was significantly upregulated in human alveolar bones diagnosed with chronic periodontitis, as assessed by RNA-seq. In the mice model of periodontitis, the alveolar bone2021-01-01T00:00:00Z2021 Apr2025-04-26T05:12:20.325Z2021-02-21T05:02:39ZS-EPMC78230533348615210.1016/j.redox.2020.101849