{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Badio M"],"funding":["National Institute of Allergy and Infectious Diseases","Innovative Medicines Initiative","Institut national de la santé et de la recherche médicale"],"pubmed_abstract":["<h4>Introduction</h4>The Ebola virus disease (EVD) outbreak in 2014-2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine. Multiple questions regarding the safety, immunogenicity, and efficacy of EVD vaccines remain unanswered. To address these gaps in the evidence base, the Partnership for Research on Ebola Vaccines (PREVAC) trial was designed. This paper describes the design, methods, and baseline results of the PREVAC trial and discusses challenges that led to different protocol amendments.<h4>Methods</h4>This is a randomized, double-blind, placebo-controlled phase 2 clinical trial of three vaccine strategies against the Ebola virus in healthy volunteers 1 year of "],"journal":["Trials"],"pagination":["86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7823170"],"repository":["biostudies-literature"],"pubmed_title":["Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries."],"pmcid":["PMC7823170"],"pubmed_authors":["Schvartz M","Williams J","Ndiaga Cisse P","Cone K","Piot P","Dembele R","Chieck K","Lane C","Bowers D","Patel S","Leigh B","Awuondo K","Jato Y","Gael Borg A","Spreng S","Woods I","Neaton J","Greijer A","Abdoulaye Camara A","Levy Y","Akpa E","Tapia M","Lysander J","Riviere P","Sow S","Jide Keshinro B","Sow Y","Seraphin J","Browne S","Stoop J","Offergeld K","Yamadjako D","Miller T","Gaignet M","Sawadogo S","D'Ortenzio E","Samai Sibiry Samake M","Kopka S","Bangura LM","Newell K","Sarro S","Howard N","Vogel S","Niouma M","Toure A","Verbruggen N","Van Der Donck KV","Akoo P","Willems W","Imes J","Thiebaut R","Beavogui AH","Gupta S","Marynissen S","Delfraissy JF","Gallagher K","Roy C","Gray M","Mahamadou I","Wentworth D","Coulibaly F","Fofana V","McCullough J","Baseler B","Coulibaly M","Lewally J","Bakare N","Muyisa Sivahera B","Dabitao D","Vincent C","Boye Cooper J","Siddiqui S","Traina S","Ilo D","Kiawu H","Nguyen VK","Akpata R","Eckes RE","Jacob W","Thompson G","Albert S","Sadio Sarro Y","Bolay F","Faye S","Pong S","Camara M","Hilton T","Camara K","Davis B","Chambelin F","Lacarra B","Tegli J","Traore A","Orsega S","Colin C","Diawara O","Hoover M","Otieno T","Snowden E","Traore M","Kombi T","Nelson M","Boison P","Hancox E","Boly A","Cahill K","Kennedy S","Lemarcis F","Esperou H","Mooney T","Coller BA","Liu K","Johnson M","Wiedemann A","Aboulhab J","Lhomme E","Morsch H","Balde A","Franklin K","Smolskis M","Pierson J","Wallet C","Sow SO","Dabakuyo-Yonli S","Tyee T","Khon B","Manno D","Wolf J","Schwimmer C","Dekeyster E","Binachon B","Nielsen L","Holley P","Yaradouno M","C Andrews B","Mercier N","Sweeney M","Splinter D","Phillips R","Neboua D","Hart G","Bockstal V","Irvine S","Sidiki Kaba A","Miranda A","Doepel L","Matthew O","Ciancia S","Lefevre A","Matard C","Shelley D","Madelaine C","Tamba S","Secka F","Eyler A","Garcia Gozalbes J","Habib Beavogui A","Hughes M","Lees S","Jusu M","Vatrinet R","Fadlu Deen G","Bauder A","Heijnen E","Falk Russell A","Connor L","Saville M","Connor N","Grund B","Katoudi J","Lukoo Ndamenyaa R","Van Roey G","Kante M","Wurie A","Bagayoko A","Onorato M","Muamba D","Haidara F","Guindo O","Neaton JD","Slater K","Diakite M","Lee S","Smout E","Damerval T","Dighero-Kemp B","Siaka Conde D","Egan A","Proffitt C","Whitworth J","Duvenhage M","Leyssen M","DuChene A","Diouf W","Ramers-Verhoeven C","Beyslow T","Couffin-Cardiergues S","Cash J","Zeggani Z","Kowuors D","Fernandez J","Termote M","Diarra A","Quach A","Yazdanpanah Y","Abdoulaye C","Assiandi SS","Douoguih M","Piziali M","Levy-Marchal C","Randunu N","Blie J","Wilson B","Greenwood B","Onwuchekwa U","Campion C","Simpson S","Cagniard B","Kieh M","Hamze B","Koivogui L","Watson-Jones D","Sanogo I","Lambert L","Gaddah A","Vallee D","Stapleton H","Peiffer-Smadj N","Simon J","Hensley L","Ortega-Perez I","Boire Y","Hensley P","Osborne C","Sangare B","Lane HC","Michavila P","Doumbia S","Lowe B","Bererd M","Diallo A","Soutthiphong AA","Moise Doumbia M","Pin Chai S","PREVAC study team","Fleck S","Marchand J","Delmas C","Badio M","Saliou Diallo M","Lacabaratz C","Enria L","Ale BM","Hebert JC","Kodio M","Etienne C","Higgs E","Barrington K","Skip I","Belson M","Ishola D","Massaquoi MBF","Wissedi N","Keita S","Wesseh C","Kirchoff M","Bawo L","Mohamed S","Grandits G","Richert L","Augier A","Barte de Saint Fare E","Tierney J","Chene G","Grue L","Masson L","Clide E","Fusco D","Kennedy SB","Anoma S","Bauduin C","Robinson C","Diop S"],"additional_accession":[]},"is_claimable":false,"name":"Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries.","description":"<h4>Introduction</h4>The Ebola virus disease (EVD) outbreak in 2014-2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine. Multiple questions regarding the safety, immunogenicity, and efficacy of EVD vaccines remain unanswered. To address these gaps in the evidence base, the Partnership for Research on Ebola Vaccines (PREVAC) trial was designed. This paper describes the design, methods, and baseline results of the PREVAC trial and discusses challenges that led to different protocol amendments.<h4>Methods</h4>This is a randomized, double-blind, placebo-controlled phase 2 clinical trial of three vaccine strategies against the Ebola virus in healthy volunteers 1 year of ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-04-28T21:40:31.312Z","creation":"2021-02-21T04:09:21Z"},"accession":"S-EPMC7823170","cross_references":{"pubmed":["33485369"],"doi":["10.1186/s13063-021-05035-9"]}}